Encapsulated Valve Adhesive Composition for On-Site Curing
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Solution Overview
Problem
Existing surgical and treatment technologies require multi-part compositions like adhesives or foams that need to be mixed before application, which can initiate setting and are unsuitable for time-sensitive or prolonged treatments.
Innovation Solution
A composition comprising a first and second component encapsulated in frangible capsules, such as lipid bilayers, that are de-encapsulated using energy or chemicals to interact and form a solid body, with a delivery structure to apply at an anatomical site.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If multi-part compositions are mixed in a single delivery device prior to injection, then the composition can be applied to the anatomical site, but the mixing initiates setting of the mixture making the procedure complex and time sensitive
Solution Approach 1:
The composition is divided into multiple separate components (first component and second component) that are delivered independently through separate lumens of the delivery device. The components remain separated during delivery and only mix after reaching the anatomical site, eliminating premature setting and reducing time sensitivity while maintaining ease of application.
2Reliability
If multi-part compositions are mixed before injection, then the composition can form adhesive or foam, but the procedure becomes complex and unsuitable for prolonged treatments
Solution Approach 1:
The adhesive composition is segmented into multiple components delivered through separate channels. The delivery device includes multiple lumens that keep components separated during delivery, reducing procedural complexity. The components mix only at the target site to form the adhesive, ensuring reliable bond formation without the complexity of pre-mixing procedures.
Solution Approach 2:
The delivery device acts as an intermediary structure with multiple lumens that facilitate the independent transport of each component to the anatomical site. This intermediary delivery system simplifies the overall procedure by managing component separation and delivery automatically, while the components themselves serve as intermediaries that combine at the target to form the final adhesive product.
3Duration of action of moving object
If components are mixed in advance, then the composition can be delivered, but setting initiation makes it unsuitable for treatments requiring extensive durations
Solution Approach 1:
The composition is segmented into stable individual components that can be stored and transported separately without setting. The first component and second component remain stable in their separated states during prolonged treatment procedures. They are delivered through separate lumens and only combine at the anatomical site, enabling both extended treatment duration and compositional stability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables in situ formation of adhesives or foams, allowing for controlled application and adherence to anatomical sites, suitable for prolonged treatments without premature setting.
Implementation Method 1
the de-encapsulation device can de-encapsulate the encapsulated component by applying energy (e.g., heat, ultrasound energy, electromagnetic radiation and/or electrical current) and/or a chemical that disrupts (e.g., ruptures) the capsules
Implementation Method 2
the frangible capsules are formed of a bi-layer of amphiphilic molecules, e.g., a lipid bilayer comprising phospholipids
Data Source
AI summary
A composition, system, and method for use at a native valve inside a heart of a subject comprises a composition that comprises a mixture that includes a first component and a second component. The second component is encapsulated in capsules in a manner that prevents its interaction with the first component until desired. The capsules are rupturable to expose the second component to the first component responsively to application of energy to the composition. Once the capsules are exposed, the composition is configured to adhere to one or more leaflets of the native valve inside the heart.