Enzyme System for Protein Extraction from Distillers Grains

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Solution Overview

Problem

In underdeveloped regions, there is a need for a cost-effective method to extract proteins from distillers grains and roots, which are currently not soluble or easily digestible, to address protein malnutrition, particularly in children, as they represent an underutilized source of protein in local diets.

Innovation Solution

A three-component enzyme system comprising a protease enzyme, a buffer to maintain pH for hydrolysis, a deactivating agent to stop the hydrolysis reaction, and a neutralizing agent to adjust pH, is used to convert proteins in distillers grains or roots into a water-soluble protein-rich broth.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If proteins in distillers grains are extracted using conventional methods, then protein availability is limited, but the process is simple and low cost

Engineering Contradiction:
Improveprotein availabilityVSAvoidprocess complexity
Core Design Contradiction:
Quantity of substanceVSEase of manufacture

Solution Approach 1:

The patent applies parameter changes by modifying pH levels through buffer addition to optimize protease enzyme activity. The buffer maintains pH in the range of 7.0-9.0, which maximizes protein hydrolysis efficiency and transforms insoluble proteins into soluble forms, thereby increasing protein availability without requiring complex equipment

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent introduces protease enzymes as intermediaries to facilitate protein extraction. These enzymes act as catalysts that break down proteins into peptides and amino acids, making them soluble and bioavailable. The enzyme system serves as a mediator between the insoluble grain proteins and the aqueous extraction medium

Inventive Principle:
Principle #24Intermediary (Mediator)

2Ease of operation

If distillers grains are used for animal feed, then protein source is available, but proteins are not soluble or easily digestible

Engineering Contradiction:
ImprovedigestibilityVSAvoidprotein solubility
Core Design Contradiction:
Ease of operationVSQuantity of substance

Solution Approach 1:

The patent changes the physical-chemical parameters of proteins through enzymatic hydrolysis. By controlling pH and temperature conditions, the insoluble protein structures are broken down into smaller, water-soluble peptides and amino acids that are easily digestible while maintaining high protein content

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent replaces mechanical grinding or physical processing methods with biochemical enzymatic hydrolysis. Instead of using mechanical force to break down protein structures, protease enzymes chemically cleave peptide bonds, achieving better solubility and digestibility without mechanical complexity

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

3Productivity

If protease enzyme is added to hydrolyze proteins, then protein hydrolysis efficiency is improved, but pH control becomes necessary

Engineering Contradiction:
Improveprotein hydrolysis efficiencyVSAvoidpH control system
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The patent introduces buffers as intermediary substances to automatically maintain pH within the optimal range for protease activity. The buffer system acts as a chemical regulator that resists pH changes during hydrolysis, eliminating the need for complex pH monitoring and adjustment equipment

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The buffer system provides self-regulating pH control through its chemical properties. It automatically neutralizes acid or base formation during protein hydrolysis, maintaining the pH window for enzyme activity without external intervention or complex control systems

Inventive Principle:
Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The enzyme system effectively hydrolyzes proteins in distillers grains or roots, producing a protein-rich broth that can supplement diets, providing essential nutrients and improving nutritional outcomes while being economically viable.

Implementation Method 1

hydrolyzing proteins of said protein-containing heated aqueous mixture of b) above by adding an effective amount of an enzyme system comprised of a protease enzyme and a buffer capable of maintaining the heated aqueous mixture at a pH effective for the hydrolysis of proteins

Methodology Applied
Scientific EffectHydrolysis: Hydrolysis

Implementation Method 2

a buffer capable of maintaining the heated aqueous mixture at a pH effective for the hydrolysis of proteins

Methodology Applied
Scientific EffectBuffering:

Implementation Method 3

stopping the hydrolysis reaction by adding a hydrolysis deactivating agent to the mixture of c) above

Methodology Applied
Scientific EffectEnzyme deactivation: Enzyme

Data Source

PatentUS9745564B2Enzyme system for extraction of proteins from distillers grains
Publication Date: 2017.08.29 ZEA10

AI summary

An enzyme system for the extraction of proteins from distillers grains and roots. The enzyme system is a three component system containing a first component of protease enzyme and a buffer, a second component comprised of a deactivating agent, and a third component comprised of neutralizing agent.