Peptidases TRIZ Cases
- Single-Layer Biodegradable Article With Water Barrier and Enzyme Activity
A PHA-polyester blend with embedded enzymes improves water resistance in single-layer biodegradable packaging without blocking polymer breakdown.
- Camel Intestinal Mucosa Extraction for Stable Unfractionated Heparin Supply
A staged camel mucosa extraction route improves heparin purity and potency while reducing dependence on porcine supply.
- PLG-Targeting dsRNA Compositions for Bleeding Reduction
Targeted dsRNA silences PLG expression to curb excessive fibrinolysis and reduce bleeding in HMB and HHT with fewer limits than standard care.
- Interfering RNA Sequences for Stable PCSK9 Gene Silencing
Specific siRNA sequences target hepatic PCSK9 mRNA to improve silencing stability while supporting LDL-C metabolism and safety.
- Self-Deliverable siRNA Knocking Down USP-10 to Reduce Scarring
Cholesterol-modified siRNA knocks down USP-10 expression, reducing fibrotic marker production and accelerating wound closure.
- Hydrophobic Chromatography for tPA Purification
Disposable hydrophobic columns separate single-chain and double-chain tPA forms via controlled solvent elution, reducing purification costs.
- dsRNA Agents Targeting CPB2 for Thrombosis Treatment
Targeted dsRNA agents reduce CPB2 protein levels by up to 95 percent, treating thrombosis without excessive bleeding risks.
- Proline-Specific Endoprotease Variant for Controlled Thermal Inactivation
Engineered polypeptide with specific amino acid substitutions enables precise control over enzymatic activity levels during processing.
- Myeloid-Specific MMP12 Mouse Model for Lung Cancer Research
A myeloid-specific c-fms-rtTA bitransgenic mouse model enables precise MMP12 induction to study immune suppression and tumorigenesis.
- PCSK9 Targeting Oligonucleotides for Hypercholesterolemia Treatment
Modified sense and antisense strands reduce PCSK9 mRNA via RNA interference, addressing insufficient LDL-cholesterol reduction in current treatments.
- Enzyme System for Protein Extraction from Distillers Grains
A three-component enzyme system hydrolyzes insoluble proteins in distillers grains into a soluble broth, addressing low digestibility and malnutrition risks.
- Recombinant Serine Proteases for Surfactant-Resistant Cleaning
Bacillus-derived recombinant serine proteases sustain hydrolysis of proteinaceous stains under alkaline conditions where standard enzymes lose function.
- Truncated Serratiopeptidase with Disulfide Bonds
Disulfide bonds between termini enhance thermal stability and membrane permeability of truncated Serratiopeptidase variants.
- Gluten-Free Wheat Starch Production via Protease Degradation
Protease treatment degrades gluten in wheat starch slurry, enabling reliable production of purified starch below 20 ppm for labeling compliance.
- Trypsin Variants for Orthogonal Polypeptide Dual-Modification
Engineered trypsin variants enable orthogonal dual-modification of polypeptides by enhancing aminolysis affinity while suppressing hydrolysis activity.