Compositions and methods for the treatment of equine protozoal myeloencephalitis

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Solution Overview

Problem

Existing treatments for Equine Protozoal Myeloencephalitis (EPM) in horses are ineffective in completely eliminating the protozoan parasites and do not address the neurological damage caused by the parasites, leading to potential relapse and irreversible neurological damage.

Innovation Solution

A formulation comprising Vitamin E Succinate, Levamisole Hydrochloride, Decoquinate, and Diclazuril, along with banana powder, is administered to horses to kill the parasites and mitigate damage, with a regimen that varies the antiprotozoal agents' introduction to target different stages of the infection.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional antiprotozoal medications are used to treat EPM, then the parasite growth is inhibited, but the treatment is ineffective in completely eliminating the parasites and does not address the neurological damage caused

Engineering Contradiction:

Improveeffectiveness of parasite eliminationVSAvoidneurological damage and relapse risk

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent combines multiple antiprotozoal agents (Decoquinate and Diclazuril) with Vitamin E Succinate and Levamisole Hydrochloride into a single composite feed formulation. This merging of substances with different functions (parasite killing and neurological protection) into one product addresses both the parasite elimination and neurological damage repair simultaneously, resolving the contradiction between effective parasite elimination and harm reduction

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention uses a composite material formulation consisting of multiple ingredients with complementary functions: Decoquinate and Diclazuril for antiprotozoal activity, Vitamin E Succinate for antioxidant and neurological protection, and Levamisole Hydrochloride for immune stimulation. This composite approach ensures both complete parasite elimination and mitigation of neurological damage, overcoming the limitations of single-substance treatments

Inventive Principle:

Principle #40Composite materials

2Loss of time

If treatment is ended before all parasites are killed, then the treatment duration is reduced, but the horse may have an EPM relapse

Engineering Contradiction:

Improvetreatment durationVSAvoidcomplete parasite elimination

Core Design Contradiction:

Loss of timeVSReliability

Solution Approach 1:

The patent employs a two-stage treatment regimen that changes the composition parameters over time. Stage 1 uses a formulation with Decoquinate, Diclazuril, Vitamin E Succinate, and Levamisole Hydrochloride for intensive parasite killing. Stage 2 transitions to a maintenance formulation with adjusted ingredients and dosages to complete elimination and prevent relapse. This parameter change approach ensures complete parasite elimination while optimizing treatment duration by adapting the formulation to different treatment phases

Inventive Principle:

Principle #35Parameter changes

3Quantity of substance

If known treatments focus on killing parasites, then the parasite load is reduced, but the damage caused by parasites is not remedied

Engineering Contradiction:

Improveparasite loadVSAvoidneurological damage

Core Design Contradiction:

Quantity of substanceVSObject-generated harmful factors

Solution Approach 1:

The patent converts the harmful effects of parasitic infection into beneficial therapeutic opportunities. Vitamin E Succinate addresses the oxidative damage and neurological injury caused by parasites through its antioxidant properties. Levamisole Hydrochloride transforms the compromised immune state into an enhanced immune response capable of both fighting parasites and repairing damage. This principle converts the harm into benefit by using the infection context to trigger protective and reparative mechanisms

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The formulation effectively kills protozoan parasites and reduces neurological damage, minimizing relapse risk and promoting recovery by enhancing the horse's immune response and providing antioxidants.

Implementation Method 1

Vitamin E Succinate as an antioxidant agent

Methodology Applied

Scientific EffectAntioxidant: Oxidation

Implementation Method 2

Levamisole Hydrochloride to elicit or amplify a horse's immune response

Methodology Applied

Scientific EffectImmune stimulation:

Data Source

PatentUS12564571B2Compositions and methods for the treatment of equine protozoal myeloencephalitis

Publication Date: 2026.03.03 GOING BIG TIME INC

AI summary

Embodiments of the invention relate to veterinary compositions and methods for the treatment of Equine Protozoal Myeloencephalitis. Specifically, embodiments of the present invention feature methods and compositions designed to treat horses with EPM by killing the protozoan parasites in the horse's body and by providing agents that limit or remedy the damage caused by the protozoan parasites. In particular embodiments, therapeutically effective amounts of Vitamin E Succinate 1185 IU, Levamisole Hydrochloride, Decoquinate, Diclazuril, and Banana powder are administered to the horse for the treatment of Equine Protozoal Myeloencephalitis.