Modified Ester Polymer Substrates for Durable Blood Compatibility
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Solution Overview
Problem
Medical instruments, particularly those requiring blood compatibility, face deterioration and loss of compatibility due to radiation sterilization, which is exacerbated by long-term storage, as existing methods do not provide adequate radical resistance.
Innovation Solution
A modified base material comprising an ester group-containing polymer is irradiated with radiation while in contact with an aqueous solution of a specific alcohol, enhancing radical resistance and maintaining blood compatibility even after repeated sterilization and storage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If hydrophilic polymers are grafted to improve blood compatibility, then blood compatibility increases, but radical generation increases leading to denaturation during storage
Solution Approach 1:
A radical scavenger is introduced as a protective intermediary that neutralizes radicals generated by the hydrophilic polymer during storage, allowing the polymer to maintain blood compatibility without causing denaturation through radical reactions
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The modified base material exhibits excellent radical resistance and sustained blood compatibility, preventing platelet adhesion and fibrinogen adsorption, ensuring effective performance over time.
Implementation Method 1
A modified base material comprising an ester group-containing polymer is irradiated with radiation while in contact with an aqueous solution of a specific alcohol
Implementation Method 2
it causes deterioration or denaturation of the materials constituting the medical instruments
Data Source
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AI summary
The present invention is characterized in that a base material comprises ester groups in the main chain and/or in the side chain(s), and comprises a polymer having hydrophobic groups. Particularly, the hydrophobic groups can be introduced by irradiating the base material with a radiation during the base material contacts an aqueous solution of a monohydric alcohol or an aqueous solution of an alcohol having not less than 2 hydroxyl groups, which is a monomer or a polymer, and which has one or more carbon atoms between the carbon atoms to each of which the hydroxyl group is bound in the monomer or in each monomer constituting the polymer.