Esterified Triglyceride Animal Nutrition Additive for Lower-Intestine Release
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Solution Overview
Problem
Existing organic acids used in animal nutrition, such as butyric and lactic acid, face challenges in reaching the lower intestine due to instability in the digestive system, leading to suboptimal delivery of their beneficial effects on intestinal microbiota.
Innovation Solution
A compound with the formula [Chem 1] is developed, which includes alkyl groups and carboxylic acids, providing stability in the upper digestive tract and controlled release in the lower intestine, enhancing the delivery of butyric and lactic acid to the intestinal microbiota.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If organic acids (butyric acid, lactic acid) are administered directly to animals, then they can exert antibacterial and nutritional effects, but they are released early in the upper intestine and do not reach the lower intestine in sufficient quantities
Solution Approach 1:
The patent uses triglyceride molecules as intermediary carriers to transport organic acids through the digestive system. The triglyceride structure protects the organic acids from premature release in the upper intestine, allowing them to reach the lower intestine where they are released to exert their beneficial effects on intestinal microbiota.
Solution Approach 2:
The patent modifies the chemical form of organic acids by converting them into esterified triglyceride derivatives. This parameter change (from free acid form to esterified form) alters their stability and release characteristics, enabling them to withstand the acidic environment of the upper intestine and release gradually in the lower intestine.
2Stability of the object's composition
If protected forms of organic acids like tributyrin are used, then resistance to stomach acid conditions is improved, but release still occurs mainly in the upper intestine with minimal reach to the lower intestine
Solution Approach 1:
The patent creates composite triglyceride molecules that combine fatty acid chains with organic acid esters in a specific structure. This composite structure provides both the stability needed to resist stomach acid (like tributyrin) and the controlled release properties needed to deliver organic acids to the lower intestine, overcoming the limitations of simple protected forms.
Solution Approach 2:
The triglyceride molecule is segmented into specific components (glycerol backbone with specific fatty acid and organic acid ester groups) that provide different functions: the fatty acid chains provide stability and resistance to acid, while the organic acid ester groups are positioned to release at specific locations in the lower intestine.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compound effectively reaches the lower intestine, promoting intestinal health by acting as an energy source, reducing inflammation, and strengthening the intestinal barrier, while being odorless and palatable, thus improving animal nutrition.
Implementation Method 1
the compound of formula [Chem 1], on the one hand, manages to reach the animal's intestine by having resisted the acidic conditions residing in the entire upstream part of the gastrointestinal tract
Implementation Method 2
once it reaches the intestine, the compound is hydrolyzed and releases butyrate which exerts numerous benefits for the intestine. It acts as a source of energy for intestinal cells
Data Source
AI summary
The disclosure concerns a use of a compound for the preparation of an additive, a premix or a food or fodder, for animal feeding, said compound corresponding to the following formula:in whichR1 is selected from C1-11 alkyl groups;R2 is selected from C1-20 alkyl groups; CmH2m—OR4; CmH2m—NHR4 where R4 is selected from H and C(O)—C1-11 alkyl and m is equal to 0 or represents an integer from 1 to 11;R3 is selected from H and C1-20 alkyl groups;n is 0 or an integer from 1 to 10; andk is an integer from 1 to 10;or a salt of said compound.