Feed Additive Composition Using Direct Fed Microbial and Enzymes
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Solution Overview
Problem
Current combinations of direct fed microbials (DFMs) with enzymes do not fully understand the interaction between these components, which limits their effectiveness in improving animal production performance and health, particularly in reducing necrotic enteritis and nutrient excretion.
Innovation Solution
A specific combination of a direct fed microbial with a protease and a phytase is used to enhance nutrient digestibility, nitrogen retention, and resistance to necrotic enteritis, while reducing nutrient excretion in manure, by administering a feed additive composition comprising these components.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If combinations of DFMs with some enzymes are used, then animal performance is improved, but the interaction between DFMs and enzymes is not fully understood, limiting effectiveness
Solution Approach 1:
The patent combines specific enzymes (protease, phytase, xylanase) with direct fed microbials (DFMs) into a unified feed additive composition. This merging allows the enzymes and DFMs to work synergistically, with enzymes pre-digesting nutrients and DFMs colonizing the gut to further enhance nutrient absorption and gut health, thereby improving animal performance while creating a predictable interaction model
Solution Approach 2:
The invention creates a composite feed additive that integrates multiple functional components: hydrolytic enzymes for nutrient breakdown, direct fed microbials for gut colonization and pathogen competition, and beneficial yeast cultures. This composite approach allows each component to contribute its specific function while working together to achieve enhanced productivity and reduced nutrient excretion
2Productivity
If conventional enzyme blends are used to improve nutrient utilization, then production performance characteristics are improved, but resistance to necrotic enteritis and reduction of nutrient excretion are not achieved
Solution Approach 1:
The patent converts the harmful effects of undigested nutrients (which fuel pathogenic bacteria and increase nutrient excretion) into beneficial effects. By combining hydrolytic enzymes that pre-digest nutrients with direct fed microbials that compete with pathogens, the system reduces available substrate for harmful bacteria, thereby preventing necrotic enteritis and reducing nutrient excretion while maintaining improved productivity
3Productivity
If DFMs are fed to animals under stress, then animal performance is improved, but the specific combination with protease and phytase has not been optimized
Solution Approach 1:
The patent optimizes the formulation by specifying precise parameter ranges for each component: enzyme activities (protease, phytase, xylanase), DFM cell counts, and ratios between components. This parameter optimization ensures that the combination delivers maximum benefit while maintaining manufacturability and stability, resolving the complexity issue through defined specifications rather than vague formulations
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination significantly improves feed conversion ratio, weight gain, and immune response, while reducing necrotic enteritis lesions and mortality, and decreases nutrient excretion in manure, demonstrating improved animal performance and health.
Implementation Method 1
a DFM in combination with a protease and a phytase has significant beneficial effects on the performance of an animal, including improving one or more of the following: feed conversion ratio (FCR), ability to digest a raw material (e.g. nutrient digestibility, such as amino acid digestibility)
Implementation Method 2
Probiotics or DFM have been shown to improve animal performance in controlled studies. DFM including direct fed bacteria and or yeast-based products... promoting the growth of beneficial bacteria in the gastrointestinal tract of a subject
Data Source
AI summary
A feed additive composition comprising a direct fed microbial in combination with a protease, and a phytase, and a method for improving the performance of a subject or for improving digestibility of a raw material in a feed (e.g. nutrient digestibility, such as amino acid digestibility), or for improving nitrogen retention, or for improving the subject's resistance to necrotic enteritis or for improving feed conversion ratio (FCR) or for improving weight gain in a subject or for improving feed efficiency in a subject or for modulating (e.g. improving) the immune response of the subject or for promoting the growth of beneficial bacteria in the gastrointestinal tract of a subject, which method comprising administering to a subject a direct fed microbial in combination with a protease and a phytase.