Ferulated Pectin Adhesives for Photocurable Tissue Sealing
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Solution Overview
Problem
Existing adhesive compositions used in medical applications, particularly for sealing surgical wounds and bonding tissues, face challenges in effectively reducing liquid or gas leakage and forming robust crosslinks upon exposure to light.
Innovation Solution
A photocurable adhesive composition comprising ferulated pectin, a photoactivatable metal-ligand complex, and an electron acceptor, which forms covalent crosslinks upon irradiation, utilizing visible light to initiate a cross-linking reaction.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional adhesive compositions are used for sealing surgical wounds, then they can bond tissues together, but they do not form robust crosslinks upon light exposure and cannot effectively reduce liquid or gas leakage
Solution Approach 1:
The patent modifies the chemical structure of pectin by introducing feruloyl groups (photoactivatable moieties) at specific positions along the polymer chain. This parameter change enables the adhesive to undergo photocrosslinking when exposed to light, transforming it from a conventional adhesive into a photocurable composition that forms robust crosslinks, thereby simultaneously improving sealing effectiveness and crosslink strength.
Solution Approach 2:
The patent creates a composite adhesive system combining ferulated pectin (modified polymer) with a photoactivatable catalyst and electron acceptor. This composite formulation enables photocrosslinking upon light exposure, forming a crosslinked network structure that provides both strong tissue bonding and effective sealing, resolving the contradiction between reliability and crosslink strength.
2Strength
If ferulated pectin is used to form photocrosslinks, then crosslink strength is improved, but the complexity of the adhesive formulation increases
Solution Approach 1:
The patent divides the adhesive formulation into distinct functional components: ferulated pectin (providing the polymer matrix and photoactivatable groups), a photoactivatable catalyst (initiating crosslinking), and an electron acceptor (facilitating the photocrosslinking reaction). This segmentation allows each component to perform its specific function while maintaining overall formulation manageability, reducing the perceived complexity despite the advanced chemistry involved.
3Strength
If photocurable components are added to enhance crosslinking, then bonding strength improves, but the ease of operation during application is reduced
Solution Approach 1:
The feruloyl groups are pre-installed on the pectin polymer chains during manufacturing, creating the photocurable adhesive composition in advance. This preliminary action prepares the material for subsequent photocrosslinking during application, allowing the surgeon to simply apply the adhesive and then activate it with light, thereby maintaining ease of operation while achieving strong bonds through the pre-prepared photocurable components.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively seals tissues and forms durable crosslinks, reducing leakage and enhancing bonding strength, suitable for medical implants and wound closure.
Implementation Method 1
irradiating a composition comprising a photoactivatable catalyst such as a photoactivatable metal-ligand complex, an electron acceptor, a ferulated pectin, and a liquid medium to initiate a cross-linking reaction
Implementation Method 2
The cross-linking reaction can form covalent crosslinks within the liquid adhesive and between the liquid adhesive and endogenous proteins of the patient tissue portion(s)
Implementation Method 3
an electron acceptor, ferulated pectin, and a liquid carrier... The electron acceptor may comprise sodium persulfate
Data Source
AI summary
In certain embodiments, the present disclosure provides adhesive compositions and graft materials comprising covalently crosslinked hydrogels, e.g. prepared or preparable by curing the adhesive compositions. In some forms, the adhesive compositions comprise a photoactivatable catalyst such as a photoactivatable metal ligand complex, an electron acceptor, a ferulated pectin, and a liquid carrier.