Fluorescent Sample Measurement With Concentration-Based Washing Control
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Solution Overview
Problem
Existing measurement systems require a fixed washing time for sample containers, which is insufficient for samples with high concentrations of fluorescent substances, leading to inadequate cleaning.
Innovation Solution
A measurement system that adjusts washing time based on the concentration of fluorescent substances by employing a first determination process to identify the intensity of the detection signal, followed by analog or digital measurement processes, and controlling the washing device for appropriate washing times based on these measurements.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a fixed washing time is used for all samples, then the washing process is simple and fast, but the washing time is insufficient for high-concentration fluorescent samples
Solution Approach 1:
The washing time is made dynamic and adjustable based on the detected fluorescent substance concentration. The control unit modifies the washing time parameter according to the measurement results, transitioning from a fixed to a variable washing duration that adapts to different sample conditions
Solution Approach 2:
The system implements feedback control where the measurement of fluorescent substance concentration directly influences the washing time parameter. The control unit uses the detection signal intensity to determine and adjust the appropriate washing duration, creating a closed-loop control system
2Reliability
If the washing time is extended for high-concentration samples, then the washing adequacy improves, but the total measurement time increases
Solution Approach 1:
The system changes the washing time parameter based on the concentration parameter of the fluorescent substance. By detecting the concentration level and adjusting the washing time accordingly, the system optimizes the balance between washing adequacy and total measurement time for different sample types
3Ease of operation
If a fixed washing time is used, then the measurement process is simple, but insufficient washing occurs for high-concentration fluorescent substances
Solution Approach 1:
The system performs self-adjustment based on automatic detection of the fluorescent substance concentration. The measurement device automatically determines the appropriate washing time without manual intervention, maintaining ease of operation while improving washing precision through automated parameter adjustment
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Ensures adequate washing of the sample container by extending the washing time for high-concentration samples, thereby improving cleaning efficiency.
Implementation Method 1
analyzing a fluorescently labeled entity contained in a sample in a sample container, depending on radiated light emitted from a fluorescent substance in the fluorescently labeled entity when excitation light is irradiated to the fluorescent substance
Data Source
AI summary
A measurement system comprises a light source configured to irradiate excitation light to a fluorescent substance kept in a sample container, the sample container containing a sample comprising the fluorescent substance, a detector configured to detect radiated light emitted from the fluorescent substance depending on the excitation light, a measurement device configured to measure a concentration of the fluorescent substance based on a detection signal detected by the detector, and a washing device configured to supply washing liquid for washing the sample container to the sample container, and the measurement device comprises a first determination unit configured to execute a first determination process. A first measurement unit is configured to execute an analog measurement and a second measurement unit is configured to execute a digital measurement.