Ganoderma lucidum extract granulation for moisture resistance
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Dietary supplements containing hygroscopic herbal powders like Ganoderma lucidum face challenges with moisture absorption, leading to reduced shelf life and production efficiency due to their porous and loose nature, which is exacerbated by the presence of non-active ingredients that dilute the active extract content.
Innovation Solution
A method involving dry granulation and self-coating of Ganoderma lucidum extract powders using a solution containing the same extract, applied through a bottom-spray fluidized bed, to create granulates with improved moisture resistance and increased bulk density, thereby minimizing moisture absorption and enhancing the active ingredient content.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If spray drying process is used to produce Ganoderma lucidum powder, then the extract can be obtained in powder form, but the powder becomes porous and loose with high moisture absorption
Solution Approach 1:
The patent divides the extract into granulated particles through granulation process, creating a segmented structure that reduces porosity and moisture absorption compared to the original powder form. The granulates have a denser, more compact structure that improves reliability.
Solution Approach 2:
The patent creates a composite structure by coating granulated extract particles with a coating material, forming a multi-layer composite that combines the extract core with a protective outer layer, improving moisture resistance while preserving the extract content.
2Ease of manufacture
If non-Ganoderma lucidum derived materials are added during processing, then the extract can be formulated more easily, but the composition contains diluting ingredients that reduce active ingredient concentration
Solution Approach 1:
The patent uses Ganoderma lucidum extract itself as the coating material, allowing the extract to coat and protect its own granulated particles. This self-service approach eliminates the need for external coating materials and additives, maintaining 100% active ingredient concentration while enabling complete coating coverage.
Solution Approach 2:
The patent creates a homogeneous composition where both the core granulates and the coating material are derived from the same Ganoderma lucidum extract, ensuring uniform composition throughout without introducing foreign or diluting ingredients.
3Quantity of substance
If granulation is performed without auxiliary excipients, then the composition remains pure Ganoderma lucidum extract, but the granulating process becomes more difficult
Solution Approach 1:
The patent employs dry granulation technology that enables the Ganoderma lucidum extract to granulate itself without requiring auxiliary excipients or binding agents. The extract's own properties facilitate the granulation process, maintaining purity while achieving complete granulation.
Solution Approach 2:
The patent replaces traditional wet granulation methods that rely on liquid binders and excipients with dry granulation technology, which uses mechanical compression and friction to form granulates directly from the powder, eliminating the need for auxiliary materials.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method results in dietary supplement compositions with reduced moisture content and porosity, improved filling efficiency, and increased active ingredient load, leading to enhanced stability and shelf life, as well as increased active ingredient presence in finished products like capsules.
Implementation Method 1
The coating material can be applied by a bottom-spray fluidized bed
Implementation Method 2
Certain herbal powders, such as Ganoderma lucidum powder, can be produced using a spray drying process
Data Source
AI summary
This document provides dietary supplement compositions. For example, this document provides dietary supplement compositions that include a Ganoderma lucidum extract.