Topical Glutathione-Cyclodextrin Composition for Stable Transdermal Delivery
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing treatments for conditions associated with glutathione depletion, such as neurological and lung diseases, alcohol and drug poisoning, and chemotherapy toxicity, are limited by glutathione's instability and poor absorption, leading to ineffective therapeutic outcomes.
Innovation Solution
A topical composition comprising reduced, nanonized L-glutathione stabilized with gamma cyclodextrin, ascorbic acid, and optional additives like dexpanthenol and sodium hyaluronate, which facilitates transdermal delivery and protects glutathione from oxidation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If glutathione is administered in conventional forms, then it can provide therapeutic effects for glutathione depletion conditions, but it suffers from instability and poor absorption leading to ineffective therapeutic outcomes
Solution Approach 1:
The patent applies parameter changes by nanonizing glutathione particles to reduce their size to the nanoscale range, which fundamentally alters the physical properties of glutathione. This size reduction increases surface area to volume ratio, enhances solubility, and improves penetration through biological barriers such as the skin, thereby resolving the contradiction between stability and therapeutic effectiveness
Solution Approach 2:
The patent uses penetration enhancers as intermediary substances that facilitate the delivery of nanonized glutathione through the skin. These enhancers temporarily modify the skin barrier properties, allowing glutathione to penetrate effectively while maintaining its stability, thus enabling therapeutic effectiveness without compromising stability
2Reliability
If glutathione is administered in conventional forms, then it can address glutathione depletion conditions, but it exhibits poor absorption preventing effective delivery to target tissues
Solution Approach 1:
By changing the physical parameter of particle size to the nanoscale, the patent dramatically improves absorption efficiency. The nanonized form of glutathione can penetrate through the stratum corneum and reach deeper skin layers and systemic circulation, enabling effective delivery to target tissues for treating various conditions
Solution Approach 2:
Penetration enhancers serve as mediators that facilitate the absorption of nanonized glutathione. These substances temporarily alter the skin barrier function, creating pathways for glutathione to penetrate efficiently, thereby achieving reliable therapeutic effectiveness
3Stability of the object's composition
If glutathione is stabilized using conventional methods, then it may improve shelf life, but it reduces bioavailability and transdermal absorption
Solution Approach 1:
The patent resolves this contradiction by nanonizing glutathione, which changes its physical state and surface properties. The nanoscale particles maintain stability during storage while simultaneously exhibiting enhanced bioavailability and transdermal absorption capabilities, allowing both stability and quantity of substance to be optimized
Solution Approach 2:
By segmenting glutathione into nanoscale particles, the patent increases the total surface area while maintaining the chemical integrity of each particle. This segmentation allows the substance to remain stable as individual particles while collectively providing high bioavailability and absorption efficiency
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition enhances glutathione bioavailability and stability, allowing effective transdermal absorption and systemic delivery, addressing a wide range of health conditions including COVID-19, herpes, and various inflammatory and oxidative stress-related disorders.
Implementation Method 1
reduced, nanonized L-glutathione stabilized with gamma cyclodextrin
Implementation Method 2
ascorbic acid; wherein the weight ratio of glutathione to ascorbic acid is between about 7:1 and 15:1
Implementation Method 3
reduced, nanonized L-glutathione that is non-esterified, non-acetylated, and non-fatty acid attached
Implementation Method 4
facilitates transdermal delivery and protects glutathione from oxidation
Data Source
AI summary
A topical composition comprising a nanonised L-glutathione and cyclodextrin complex, together with ascorbic acid in a weight ratio of glutathione to ascorbic acid from 7:1 to 15:1 and from 1:1 to 1:15 and a further compound comprising dexpanthenol, thiamine, benzalkonium chloride, sodium hyaluronate or acetyl-L-cysteine, which composition is topically administered for treating the symptoms of viral infection including COVID-19 and influenza, and for treating herpes simplex, herpes zoster, post herpetic neuralgia, genital herpes, alcohol detoxification, high triglycerides, age or liver spots and lupus.