Nervous Disorder TRIZ Cases

Genotyping CYP2D6, COMT, and transporter genes guides ADHD drug and dose selection to reduce trial and error and side effects.

Acetyl-leucine treatment targets lysosomal storage disorders by reducing lysosomal volume, slowing symptom progression, and improving clinical outcomes.

CSF delivery spreads engineered T cells beyond local injection sites, improving CNS tumor access, persistence, and survival with low toxicity.

Spatially separated growth cues in bifurcated nerve conduits selectively guide motor and sensory regeneration to improve repair and feedback.

Selective purine NR2B modulators improve brain penetration and metabolic stability while reducing dissociative side effects.

Independent cell-adhesive regions in one shared medium enable uniform stem cell seeding and more stable, scalable neural organoid production.

A CBD+CBG composition improves dopaminergic neuron viability and dopamine secretion while avoiding THC-related addiction and side effects.

Uses defective integrase and episomal replication to sustain transient gene expression while avoiding random integration and toxicity.

A small-molecule CD73 inhibitor blocks AMP-to-adenosine conversion to improve specificity and anti-tumor activity in CD73-mediated disease.

A Lactobacillus salivarius composition targets oxidative stress, cytokine imbalance, and gut barrier damage to slow Parkinson's progression.

Using memantine enanthate in a transdermal patch prevents crystal precipitation while improving skin permeability and reducing irritation.

Using fibrillary ApoE to trigger a targeted immune response offers a route to slow or reverse Alzheimer's disease progression.

Small brain-permeable ABCA1 activators directly boost apoE4 lipidation, reduce amyloid β buildup, and avoid peptide delivery limits.

A coenzyme Q10, vitamin D, vitamin B2, PUFA, and choline composition supports neurite outgrowth and reduces neuronal damage after stroke.

Specific phenalkylamine substitutions improve mood disorder treatment while lowering abuse potential through controlled receptor activity and dosing.

Allosteric D3 receptor modulators improve D3 over D2 selectivity, reducing off-target effects in CNS disorder treatment.

Nanonized glutathione stabilized by gamma cyclodextrin and ascorbic acid improves transdermal absorption while limiting oxidation.

A crystalline lemborexant-succinic acid form improves stability, dissolution, and handling through controlled crystallization.

Salting hexylamine with succinic or citric acid reduces odor and toxicity while improving stability, dissolution, and supplement suitability.

A thioic acid ALS therapy case showing how (2S)-2-aminopentanethioic S-acid reduces oxidative stress, paralysis, and motor dysfunction.