Stroke Nutrition Composition for Neuronal Recovery Support
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Solution Overview
Problem
Current treatments for stroke, particularly ischemic stroke, are limited in promoting neuronal recovery and regeneration, with existing pharmaceutical and nutritional interventions showing little effectiveness in improving functional outcomes and being time-constrained.
Innovation Solution
A nutritional composition comprising coenzyme Q10, vitamin D, vitamin B2, polyunsaturated fatty acids, and choline, optionally with additional B vitamins and phospholipids, is administered to enhance neurite outgrowth and reduce neuronal damage after hypoxia, supporting neuronal repair and recovery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If reperfusion therapy with recombinant tissue plasminogen activator is administered, then blood flow restoration is achieved, but treatment time window is limited to within 4.5 hours of stroke onset
Solution Approach 1:
The nutritional composition is administered as a preventive measure before stroke occurs or in the early stages, preparing the body with neuroprotective nutrients (coenzyme Q10, vitamin D, vitamin B2, polyunsaturated fatty acids, and choline) that support neuronal survival and reduce damage. This preliminary nutritional preparation extends the effective treatment window beyond the 4.5-hour limitation of reperfusion therapy alone.
2Ease of operation
If traditional rehabilitation is provided, then basic care is maintained, but functional recovery is limited with little effect on neuronal regeneration
Solution Approach 1:
The invention changes the biochemical parameters of the patient's system by administering specific nutrients (coenzyme Q10, vitamin D, vitamin B2, polyunsaturated fatty acids, and choline) that directly support neuronal metabolism, reduce oxidative stress, and promote neuroplasticity. This biochemical modification enhances the effectiveness of rehabilitation by creating a physiological environment more conducive to neuronal regeneration and functional recovery.
3Device complexity
If single-nutrient supplementation is provided, then specific nutrient deficiency is addressed, but comprehensive neuronal recovery is not achieved
Solution Approach 1:
The invention merges five key nutrients (coenzyme Q10, vitamin D, vitamin B2, polyunsaturated fatty acids, and choline) into a single comprehensive nutritional composition. Each nutrient addresses a specific aspect of neuronal health: coenzyme Q10 for mitochondrial energy production, vitamin D for neuroprotection, vitamin B2 for metabolic support, polyunsaturated fatty acids for membrane integrity, and choline for acetylcholine synthesis. Their combination creates a synergistic effect that comprehensively supports neuronal recovery and regeneration.
Data Source
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AI summary
The invention relates to a nutritional composition comprising a combination of (i) co-enzyme Q10 with (ii) vitamin D and (iii) vitamin B2, for use in the treatment of stroke, preferably ischemic stroke. The invention also relates to a composition comprising a combination of co-enzyme Q10 and vitamin D, and vitamin D3 with optionally polyunsaturated fatty acids selected from DHA, EPA and/or DPA; and/or choline, choline salts and/or choline esters.