Gravity-Positioned Oral Pill for Controlled Drug Release
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Solution Overview
Problem
Oral drug delivery systems face challenges due to rapid degradation in the gastrointestinal tract and poor penetration of large molecules, leading to short residence time and low bioavailability, necessitating high doses and frequent administration.
Innovation Solution
A method involving an oral pill or device with a higher density than gastric contents, using gravity to position itself against stomach/intestinal tissue, incorporating additives like salts, sugars, or metals to ensure contact and controlled release, protected by a low-density layer.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If gelatin capsule is used to protect formulation from premature exposure, then protection from degradation is improved, but adhesion to tissue causes fouling and interferes with drug release
Solution Approach 1:
The capsule is divided into two distinct layers: an outer gelatin shell for protection and an inner matrix composition containing the drug substance. This segmentation allows the protective function and drug release function to be separated, preventing the gelatin from fouling the tissue surface while still providing protection during transit.
Solution Approach 2:
The matrix composition acts as an intermediary layer between the gelatin capsule and the tissue surface. It provides a non-adherent interface that prevents direct contact between the gelatin and tissue, eliminating the fouling problem while maintaining the protective function of the gelatin shell.
2Speed
If quick erosion of oral drug delivery is used for rapid release, then release speed is improved, but residence time becomes too short reducing bioavailability
Solution Approach 1:
The matrix composition uses controlled erosion parameters through specific polymer selection and formulation to achieve a balanced release profile. By adjusting the erosion rate parameters, the system maintains extended contact with the tissue surface while providing sufficient drug release, optimizing both release speed and residence time for improved bioavailability.
3Quantity of substance
If high dose and high dosing frequency are used to overcome poor penetration, then therapeutic outcome is improved, but patient convenience and compliance worsen
Solution Approach 1:
The controlled erosion matrix provides continuous drug release over an extended period, maintaining therapeutic levels without requiring frequent dosing. This continuous action allows for lower individual doses with less frequent administration, improving patient compliance while maintaining therapeutic effectiveness.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enhances drug absorption by minimizing degradation and improving penetration across the epithelium, allowing for faster, more controlled, and consistent drug delivery.
Implementation Method 1
using gravity to position itself against stomach/intestinal tissue
Implementation Method 2
A method involving an oral pill or device with a higher density than gastric contents
Data Source
AI summary
The present invention discloses a method of enabling a better and more controlled drug release from an oral administered pill and/or an oral delivery device by using gravity adding weight/high density content to secure that the pill/device decent through the stomach fluids and come in close contact with stomach and/or intestine tissue as it dissolves/releases the drug enabling a better controlled absorption/transfer of the drug to the blood stream.