Photo-Crosslinkable HA Copolymer Tissue Adhesive Without Phase Separation
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Solution Overview
Problem
Conventional medical tissue adhesives, such as cyanoacrylate and fibrin-based adhesives, suffer from issues like poor adhesion on wet surfaces, toxicity, low biocompatibility, and limited flexibility, while photo-crosslinkable hyaluronic acid adhesives face challenges with poor mechanical properties and limited applicability.
Innovation Solution
A copolymeric hyaluronic acid compound with varying photo-crosslinking lengths is developed, forming multilength networks to enhance mechanical properties and adhesiveness, preventing phase separation and enabling biodegradability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If conventional cyanoacrylate-based tissue adhesives are used, then fast adhesive performance is achieved, but poor adhesion on wet surfaces and toxicity occur
Solution Approach 1:
The patent changes the chemical composition parameters by using hyaluronic acid backbone with photo-crosslinkable groups instead of conventional cyanoacrylate chemistry. This parameter change enables the adhesive to maintain fast bonding speed while eliminating toxicity and improving wet surface adhesion through the unique properties of hyaluronic acid and photo-initiated crosslinking
Solution Approach 2:
The patent creates a composite material system combining hyaluronic acid polymer chains with photo-crosslinkable functional groups (methacrylate or acrylate groups). This composite structure integrates the biocompatibility and wet adhesion of hyaluronic acid with the rapid crosslinking capability of photo-initiated polymers, resolving the contradiction between speed and safety
2Reliability
If conventional photo-crosslinkable HA is used, then photo-crosslinking capability is achieved, but poor flexibility and difficulty in controlling physical properties occur
Solution Approach 1:
The patent employs parameter changes by systematically varying the ratio of methacrylate to acrylate functional groups on the hyaluronic acid chains. By controlling the proportion of these photo-crosslinkable groups (0-10 per disaccharide unit), the patent achieves precise control over crosslinking density, gel strength, flexibility, and degradation rate, thereby resolving the contradiction between reliable photo-crosslinking and adjustable physical properties
Solution Approach 2:
The patent introduces dynamic control over the adhesive's physical properties through adjustable functional group ratios. The material can be dynamically tuned during formulation to achieve different mechanical properties, flexibility levels, and degradation profiles while maintaining photo-crosslinking capability, enabling adaptation to various application requirements
3Device complexity
If single-component adhesive systems are used, then simplicity is achieved, but phase separation occurs reducing mechanical properties
Solution Approach 1:
The patent achieves homogeneity by incorporating multiple photo-crosslinkable functional groups (methacrylate and acrylate) directly onto the hyaluronic acid backbone in a copolymer structure. This homogeneous distribution of crosslinkable groups throughout the single polymer chain prevents phase separation during crosslinking, maintaining both system simplicity and enhanced mechanical properties through uniform network formation
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The copolymer provides excellent elongation, mechanical strength, and adhesion to skin and mucosal tissues, suitable for various medical applications including hemostasis, wound dressing, and anti-adhesion, without phase separation.
Implementation Method 1
a photo-crosslinkable tissue adhesive, capable of maintaining high adhesion with tissues by forming a hydrogel on the spot by light such as UV
Data Source
AI summary
The present invention relates to the manufacture of a photo-crosslinkable biodegradable tissue adhesive using a multinetwork-forming copolymer, and provides a hyaluronic acid copolymer compound having excellent elongation, mechanical properties, and tissue adhesion. The compound fundamentally does not undergo phase separation, and enables the manufacture of a tissue adhesive with desired adhesive characteristics and physical characteristics.