Hemostatic Composite Sponge for Impaired Coagulation
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing collagen-based hemostatic pads fail to induce hemostasis effectively under conditions of impaired coagulation, such as heparinization, and lack sufficient adherence to tissue.
Innovation Solution
A hemostatic porous composite sponge comprising a biomaterial matrix with a hydrophilic polymeric cross-linker, such as polyalkylene oxide polymer, coated or impregnated onto the matrix, allowing cross-linking with blood and tissue proteins to form a sealing gel.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If collagen pads are used for hemostasis, then platelet aggregation and thrombin formation occur, but hemostasis is not effective under impaired coagulation conditions
Solution Approach 1:
The invention changes the chemical parameters of the collagen pad by incorporating electrophilic crosslinkers (such as glutaraldehyde, epichlorohydrin, or carbodiimides) that react with blood proteins to form covalent bonds. This chemical modification enables the pad to function effectively even when the natural coagulation cascade is impaired, as the crosslinking mechanism does not depend on functional coagulation factors.
Solution Approach 2:
The invention creates a composite material by combining collagen with electrophilic crosslinking agents. This composite structure provides both the hemostatic properties of collagen (platelet aggregation, thrombin formation) and the adhesive sealing properties of the crosslinked network, making the material effective under both normal and impaired coagulation conditions.
2Strength
If collagen pads are used for wound healing, then tissue adhesion occurs, but adherence strength is insufficient
Solution Approach 1:
The invention modifies the physical-chemical parameters of the collagen pad surface through electrophilic crosslinking, creating reactive groups that form strong covalent bonds with tissue proteins. This chemical bonding mechanism significantly enhances adherence strength compared to simple physical adhesion, providing reliable wound coverage stability.
Solution Approach 2:
The electrophilic crosslinker acts as an intermediary between the collagen pad and the tissue. It forms covalent bonds with both the collagen matrix and tissue proteins, creating a strong chemical bridge that enhances adherence strength and ensures reliable wound coverage.
3Quantity of substance
If collagen pads are used for hemostasis, then swelling occurs, but swelling behavior is excessive
Solution Approach 1:
The invention changes the structural parameters of the collagen matrix through electrophilic crosslinking, creating a more rigid and stable network structure. This crosslinked structure maintains the porosity needed for fluid absorption while controlling the degree of swelling, preventing excessive expansion that would compromise hemostatic effectiveness.
Solution Approach 2:
The crosslinked collagen-cement composite structure provides a balanced matrix that maintains appropriate porosity for fluid absorption while the crosslinked network prevents excessive swelling. This composite structure ensures stable composition during the hemostatic process.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The sponge enhances hemostasis and adherence to tissue, providing effective wound coverage and sealing, especially in conditions of impaired coagulation, with improved swelling behavior and absorption capabilities.
Implementation Method 1
a single hydrophilic polymeric component, said polymeric component comprising electrophilic reactive groups, wherein said hydrophilic polymeric component is a hydrophilic crosslinker... allowing cross-linking with blood and tissue proteins to form a sealing gel
Implementation Method 2
Upon wetting of this composition at an appropriate pH a reaction between the 2 components takes place and a gel with sealing properties is formed
Data Source
Figure 1
Figure 2
Figure 3
AI summary
The present invention provides a hemostatic porous composite sponge comprising i) a matrix of a biomaterial and ii) one hydrophilic polymeric component comprising reactive groups wherein i) and ii) are associated with each other so that the reactivity of the polymeric component is retained, wherein associated means that - said polymeric component is coated onto a surface of said matrix of a biomaterial, or - said matrix is impregnated with said polymeric material, or - both.