Biodegradable Superabsorbent Hemostatic Powder for Surgical Bleeding Control
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Solution Overview
Problem
Existing powder-type hemostatic agents face challenges with effective blood absorption and tend to flow with bleeding fluid, making them less suitable for surgical and minimally invasive procedures.
Innovation Solution
A topical hemostatic powder composition incorporating a biodegradable superabsorbent polymer (Bio-SAP) and a bioadhesive polymer (BP), which are combined using specific crosslinking agents to form a structure that enhances blood absorption and adhesion, thereby improving hemostatic efficacy and usability in surgical procedures.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If conventional powder-type hemostatic agents are used, then they are easy to store and handle, but they flow with bleeding fluid and have poor blood absorption effectiveness
Solution Approach 1:
The patent combines superabsorbent polymer particles (SAP) with bioadhesive polymer particles to create a composite hemostatic powder. The SAP component provides excellent blood absorption capacity while the bioadhesive polymer ensures the powder adheres to bleeding sites and does not flow away with blood fluid. This composite structure resolves the contradiction between ease of handling and blood absorption effectiveness.
Solution Approach 2:
The superabsorbent polymer component possesses a porous structure that enables rapid and efficient blood absorption. The porous network allows blood to be drawn into the polymer matrix through capillary action and osmotic pressure, significantly improving blood absorption effectiveness while maintaining the powder form for easy storage and handling.
2Reliability
If existing hemostatic agents are used, then they can stop bleeding, but they are not biodegradable and may cause thrombosis requiring retransfusion
Solution Approach 1:
The patent selects biodegradable superabsorbent polymer materials that can be metabolized by the body. These polymers are designed with specific chemical compositions and molecular structures that allow them to break down into harmless byproducts through hydrolysis and enzymatic degradation, eliminating thrombosis risk while maintaining effective hemostasis.
Solution Approach 2:
The patent converts the potential harmful effect of non-biodegradable materials causing thrombosis into a benefit by selecting biodegradable polymers. The degradation products of these polymers are naturally excreted by the body, transforming what would be a harmful persistent foreign body into a temporarily useful hemostatic agent that safely disappears after performing its function.
3Reliability
If conventional hemostatic agents are used, then they provide basic hemostasis, but they lack adhesion and cannot remain in place during surgical procedures
Solution Approach 1:
The patent creates a composite where bioadhesive polymer particles are combined with superabsorbent polymer particles. The bioadhesive component contains functional groups that interact with tissue proteins and cell surfaces, providing strong adhesion to the bleeding site. This ensures the hemostatic powder remains in place during surgical procedures while maintaining its blood absorption capability.
Solution Approach 2:
The bioadhesive polymer acts as an intermediary between the superabsorbent polymer particles and the tissue surface. It provides the bonding interface that anchors the hemostatic agent to the bleeding site, allowing the SAP particles to remain positioned where they can effectively absorb blood while adhering to the tissue.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition provides excellent biodegradability, improved blood absorption, and ease of use, reducing the risk of retransfusion due to thrombosis, and is applicable in endoscopic and laparoscopic procedures, offering enhanced hemostatic efficacy and safety.
Implementation Method 1
a biodegradable superabsorbent polymer (Bio-SAP) having a structurally crosslinked polymer structure and having an ability to absorb moisture such as a fluid including water or moisture
Implementation Method 2
significantly improve blood absorption
Implementation Method 3
having an ability to absorb moisture such as a fluid including water or moisture
Implementation Method 4
a biodegradable superabsorbent polymer (Bio-SAP) having a structurally crosslinked polymer structure
Implementation Method 5
a bioadhesive polymer (BP)
Implementation Method 6
biodegradable superabsorbent polymer
Implementation Method 7
biodegradable
Data Source
AI summary
A topical hemostatic powder composition and a preparation method for manufacturing the powder composition are disclosed. The powder-type hemostatic agent includes a superabsorbent polymer and a bioadhesive polymer (BP). The power-type hemostatic agent is biodegradable in vivo and superb in terms of hemostasis effectiveness, thereby suitable for various applications in surgical procedures and minimal invasive surgery such as endoscopy, laparoscopy, and the like.