Herbal Extract Composition for Selective Anticancer Activity

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Current cancer therapeutic agents are toxic and non-selective, leading to significant side effects and limited efficacy in preventing and treating various types of cancer.

Innovation Solution

A pharmaceutical, food, and feed composition utilizing a mixed extract of Angelica gigas, Aconitum carmichaeli Debeaux, and Zingiber officinale Roscoe, with a mixing ratio of 1.5 to 2.5 : 0.5 to 1.5 : 0.5 to 1.5, which effectively suppresses cancer cell proliferation and viability.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If current cancer therapeutic agents are used, then cancer cells can be removed, but toxicity and side effects increase significantly

Engineering Contradiction:

Improvecancer cell removal effectivenessVSAvoidtoxicity and side effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent divides the anticancer activity into multiple components by using a combination of three different herbal extracts (Angelica gigas, Aconitum carmichaeli, and Zingiber officinale) instead of a single compound. Each extract contributes specific bioactive compounds that work synergistically to target cancer cells while reducing individual toxicity levels.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The invention creates a composite herbal formulation combining three distinct plant extracts with complementary pharmacological properties. This composite approach allows the mixture to achieve enhanced anticancer efficacy while the diverse chemical compositions buffer against the toxic effects of individual components.

Inventive Principle:

Principle #40Composite materials

2Reliability

If current cancer therapeutic agents are used, then some cancer treatment effect is achieved, but selectivity is poor and normal cells are affected

Engineering Contradiction:

Improvecancer treatment effectivenessVSAvoidselectivity for cancer cells

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent applies local quality by having different herbal extracts target specific aspects of cancer cell pathology. Angelica gigas provides antioxidant and anti-inflammatory properties, Aconitum carmichaeli contributes cardioprotective and anticancer compounds, and Zingiber officinale adds anti-nausea and digestive benefits, creating a multi-faceted attack on cancer while sparing normal tissues.

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

The herbal extracts serve as natural intermediaries that mediate between the therapeutic goal of killing cancer cells and the need to protect normal cells. The plant compounds act as selective mediators that preferentially affect cancerous tissue through apoptosis induction while maintaining safety profiles better than conventional chemotherapy agents.

Inventive Principle:

Principle #24Intermediary (Mediator)

3Reliability

If single herbal extracts are used for cancer treatment, then specific pharmacological effects are achieved, but comprehensive anticancer activity is limited

Engineering Contradiction:

Improvespecific pharmacological effectVSAvoidoverall anticancer efficacy

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The patent merges three separate herbal extracts into a unified formulation, combining their individual pharmacological effects into a synergistic whole. The combination of Angelica gigas (blood-enriching), Aconitum carmichaeli (gateway-opening and warming), and Zingiber officinale (digestive and circulatory stimulation) creates enhanced anticancer activity greater than the sum of individual components.

Inventive Principle:

Principle #5Merging (Combining)

Data Source

PatentEP4023236B1Composition for preventing or treating cancer comprising angelica gigas, aconitum carmichaeli debeaux, and zingiber officinale roscoe mixed extract as active ingredient

Publication Date: 2026.03.18 UNIVERSITY INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY

Figure 1~2
Figure 3~4
Figure 5~6

AI summary

The present invention relates to a composition for preventing or treating cancer comprising a mixed extract of Angelica gigas, Aconitum carmichaeli Debeaux, and Zingiber officinale Roscoe as an active ingredient, more particularly to a pharmaceutical composition, a food composition, and a feed composition for preventing or treating cancer including a mixed extract of Angelica gigas, Aconitum carmichaeli Debeaux, and Zingiber officinale Roscoe as an active ingredient; a method for preventing or treating cancer comprising a step of administering the pharmaceutical composition; and a use for preventing or treating cancer. Angelica gigas, Aconitum carmichaeli Debeaux, or Zingiber officinale Roscoe of the present invention exhibits excellent cancer treatment effects, and therefore can be included in a pharmaceutical composition or a food as an active ingredient to be used in development of cancer treatment or amelioration agents and the like.