Herbal Extract Mixture for Hypertension via Vasodilation
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Solution Overview
Problem
Current hypertension treatments often require multiple medications and can have adverse effects due to long-term use, and there is a need for a more effective and safer alternative that can address hypertension and related complications.
Innovation Solution
A medicament composed of a specific combination of 95% ethanolic extracts of Uncaria rhynchophylla, 95% ethanolic extract of Pueraria thomsonii, 95% ethanolic extract of Panax notoginseng, and 50% ethanolic extract of Alisma orientale, in a particular ratio, extracted using 50% ethanol, which is used to treat hypertension and related complications by inducing vasodilation and regulating vascular tone.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If multiple anti-hypertensive drugs are used for treatment, then blood pressure control effectiveness is improved, but adverse effects and safety issues worsen
Solution Approach 1:
The patent combines four different TCM herbs (Uncaria rhynchophylla, Pueraria thomsonii, Panax notoginseng, and Alisma orientale) into a composite formulation where each herb contributes different therapeutic mechanisms. This composite approach achieves synergistic blood pressure control while reducing reliance on multiple Western medications and their associated side effects
Solution Approach 2:
The patent optimizes the weight ratios of the four herbs through systematic experimentation to achieve the most effective formulation. By adjusting the parameters of herb composition and proportions, the treatment achieves maximum efficacy with minimum adverse effects
2Object-affected harmful factors
If TCM herbs are used for treatment, then safety and adverse effects profile are improved, but treatment effectiveness may worsen
Solution Approach 1:
The patent merges four TCM herbs with complementary therapeutic actions into a single integrated formulation. Each herb addresses different aspects of hypertension pathophysiology, and their combined effect produces synergistic benefits that enhance overall treatment effectiveness while maintaining the safety profile of natural herbs
Solution Approach 2:
The herb combination serves multiple therapeutic functions simultaneously: vasodilation, calcium channel blocking, antioxidant protection, and anti-inflammatory effects. This multi-functionality allows a single TCM formulation to address hypertension through multiple mechanisms, matching or exceeding the effectiveness of conventional medications
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively reduces blood pressure in spontaneous hypertensive rats and exhibits significant vasodilatory effects by employing various signaling pathways and potassium channels, demonstrating a novel approach to treating hypertension with fewer side effects.
Implementation Method 1
The composition effectively reduces blood pressure in spontaneous hypertensive rats and exhibits significant vasodilatory effects by employing various signaling pathways and potassium channels
Implementation Method 2
exhibits significant vasodilatory effects by employing various signaling pathways and potassium channels
Data Source
AI summary
The present invention relates to a hypertension treatment. More particularly, the present invention relates to combination of four herbs' extract including 95% ethanolic extract of U. rhynchophylla (UR95), 95% ethanolic extract of P. thomsonii (PT95), 95% ethanolic extract of P. notoginseng (PN95), and 50% ethanolic extract of A. orientale (AO50) in particular range of ratio (known as F1 ratio), and all the raw herbs were then extracted in total by using 50% ethanol (known as F1-2) for use in a medicament for treating hypertension and hypertension-related complications and a composition thereof.