Targeted RNA-seq screening identifies compounds that restore dysregulated valve gene expression, reduce calcification, and may delay CAVD progression.
Varenicline activates α7nAChR to suppress reperfusion-driven inflammation, oxidative stress, and fibrosis while preserving organ function.
Nucleic acid miR-92 antagonists target reduced ventricular elasticity and diastolic dysfunction to improve outcomes in HFpEF.