Cardiovascular Disorder TRIZ Cases
- Cardiac Valve Therapy Using Targeted RNA-Seq Drug Screening
Targeted RNA-seq screening identifies compounds that restore dysregulated valve gene expression, reduce calcification, and may delay CAVD progression.
- α7nAChR Agonist Composition for Ischemia-Reperfusion Inflammation
Varenicline activates α7nAChR to suppress reperfusion-driven inflammation, oxidative stress, and fibrosis while preserving organ function.
- miR-92 Antagonists for HFpEF Diastolic Dysfunction
Nucleic acid miR-92 antagonists target reduced ventricular elasticity and diastolic dysfunction to improve outcomes in HFpEF.
- ALDH4A1-Targeted Antibodies for Atherosclerotic Plaque Diagnosis
ALDH4A1-binding A12 antibodies enable atherosclerotic plaque imaging and treatment while delaying progression and lowering LDL.
- Selective PDE2 Inhibition for Ventricular Tachycardia Treatment
Selective PDE2 inhibition targets ventricular tachycardia while reducing Ca2+ loading.
- NEP Inhibitor–Azilsartan Composition for Stable Heart Failure Therapy
Combining NEP inhibition with azilsartan supports steadier cardiovascular treatment.
- Herbal Extract Mixture for Hypertension via Vasodilation
A four-herb extract composition induces vasodilation to reduce blood pressure.
- Peony Root Extract Inhibits Advanced Glycation End Products
Peony root extract composition inhibits advanced glycation end product generation to treat vascular conditions.
- Gamma-ketoaldehyde scavengers for atherosclerosis plaque stabilization
2-HOBA targets reactive lipid dicarbonyls to attenuate atherosclerosis without disrupting normal ROS signaling.
- Chinese Medicine Composition for Myocardial Infarction Secondary Prevention
A Chinese medicine composition reduces re-infarction and death events in post-myocardial infarction patients.
- Deuterated Cardiovascular Drug Compositions for Bradycardia
Deuterium substitution at specific carbon positions extends pharmacokinetic half-life, reducing adverse side effects and avoiding invasive pacemaker surgery.
- Traditional Chinese Medicine Potassium Channel Modulator for Arrhythmia
A composite traditional Chinese medicine formulation regulates potassium channels to modulate action potential duration in myocardial cells.
- ASO Splicing Modulators for Timothy Syndrome Exon 8A
Antisense oligonucleotides target CACNA1C exon 8A inclusion, resolving underlying splicing defects in Timothy syndrome.
- DNA Aptamer Inhibiting TXNDC5 Catalytic Activity for Fibrosis
A DNA aptamer binds specifically to TXNDC5 protein to inhibit its catalytic activity.
- Antisense Oligonucleotides Targeting GATA4 uORF for Cardiac Hypertrophy
Antisense oligonucleotides bind GATA4 mRNA to inhibit protein expression, addressing the lack of universal therapies for cardiac hypertrophy.
- GSNOR Inhibitor Adjunct Therapy for Stroke Reperfusion
Administering a GSNOR inhibitor with remote ischemic conditioning restores microcirculatory flow in stroke patients with comorbidities.
- Soy Sauce Peptide Retention via Controlled Protease Activity
Controlled protease activity in soy sauce koji prevents peptide degradation during fermentation, retaining hypotensive effects.
- Salvia haenkei extract for cardiac fibrosis and arrhythmia treatment
Salvia haenkei extract prevents collagen deposition and reduces interstitium rigidity to address cardiac fibrosis.
- MAPK Inhibitors Extend Ischemic Stroke Treatment Window
MAPK pathway inhibitors extend the therapeutic window for ischemic stroke treatment by blocking signaling cascades that drive penumbral damage.
- Subtherapeutic RAAS and HMG-CoA Inhibitors for Arterial Wall Protection
Combining subtherapeutic doses of RAAS and HMG-CoA reductase inhibitors to maintain arterial wall functional properties.
- Eicosapentaenoic Acid Modulation of Membrane Lipid Packing and Oxidation
Eicosapentaenoic acid stabilizes membrane polyunsaturated fatty acids against oxidation through electron donation.