Traditional Chinese Medicine Potassium Channel Modulator for Arrhythmia

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Solution Overview

Problem

Current treatments for arrhythmias, including traditional Chinese medicine, have limited application range and are associated with side effects, and there is a need for a potassium channel regulator that can effectively prolong action potential duration without toxic effects.

Innovation Solution

A combination of traditional Chinese medicine ingredients, including Coptidis Rhizoma, Poria, Pinelliae Rhizoma, Aurantii Fructus, Dichroae Radix, Ginseng Radix Et Rhizoma, Ophiopogonis Radix, Sophorae Flavescentis Radix, Glycyrrhizae Radix Et Rhizoma, and Artemisiae Annuae Herba, is formulated to regulate potassium channels and prolong action potential duration, inhibiting arrhythmias induced by excitatory reentry.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If chemical drugs (Class I-IV) are used to treat arrhythmias, then arrhythmia symptoms are suppressed, but toxic side effects and limited application range occur

Engineering Contradiction:

Improvearrhythmia treatment efficacyVSAvoidtoxic side effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent uses a composite traditional Chinese medicine formula containing multiple herbs (Coptis chinensis, Pinellia ternata, Aconitum carmichaelii, etc.) to create a multi-component pharmaceutical composition that regulates potassium channels. This composite approach combines synergistic effects of different herbs to achieve arrhythmia treatment while reducing toxic side effects associated with single chemical drugs.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent modifies the treatment approach by changing from conventional chemical drug parameters to traditional Chinese medicine parameters, including specific herb combinations, dosages (e.g., Coptis 10-30g, Pinellia 10-20g), and preparation methods. These parameter changes enable prolonged action potential duration without the toxic effects of conventional antiarrhythmic drugs.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If existing traditional Chinese medicine (Xinsuning capsule) is used, then some arrhythmia symptoms are treated, but application range is very limited

Engineering Contradiction:

Improvetreatment effect on ventricular premature beatVSAvoidapplication range

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent enhances the universality of traditional Chinese medicine treatment by formulating a multi-functional pharmaceutical composition that can treat various types of arrhythmias including ventricular premature beats, atrial fibrillation, supraventricular tachycardia, and ventricular tachycardia. The formula achieves multiple therapeutic effects through potassium channel regulation, extending application beyond the limited scope of existing TCM treatments.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent expands application range by creating a composite formula with ten different traditional Chinese medicine ingredients, each contributing specific therapeutic effects. This comprehensive composition addresses diverse arrhythmia mechanisms through synergistic actions on potassium channels, making it applicable to multiple arrhythmia types rather than a single condition.

Inventive Principle:

Principle #40Composite materials

3Duration of action of moving object

If potassium channel blockers are used to prolong action potential duration, then arrhythmia is treated, but toxic side effects occur

Engineering Contradiction:

Improveaction potential durationVSAvoidtoxic side effects

Core Design Contradiction:

Duration of action of moving objectVSObject-affected harmful factors

Solution Approach 1:

The patent replaces long-term toxic chemical potassium channel blockers with a natural traditional Chinese medicine formulation that achieves the same therapeutic effect (prolonging action potential duration) without cumulative toxicity. The herbal composition provides sustained potassium channel regulation through metabolizable natural compounds, eliminating the need for continuous high-dose chemical intervention that causes side effects.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent converts the potentially harmful effect of excessive potassium channel blocking into a beneficial therapeutic effect by using traditional Chinese medicine ingredients that gently modulate channel activity. The herbal formulation achieves prolonged action potential duration through natural compounds that regulate rather than forcibly block channels, transforming the harmful mechanism of chemical blockers into a beneficial physiological modulation.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Data Source

PatentUS11160841B2Method of treating a disease associated with potassium ion channel

Publication Date: 2021.11.02 SHAANXI MOMENTUM QIXUEHE PHARMACEUTICAL CO LTD

AI summary

An application of a combination of traditional Chinese medicine in the preparation of a potassium ion channel modulating agent. The combination of traditional Chinese medicine is made up of traditional Chinese medicine raw materials according to the following weight proportion: Coptidis Rhizoma 250˜450; Pinelliae Rhizoma 150˜350; Poria 150˜450; Aurantii Fructus Immaturus 62˜265; Dichroae Radix 150˜350; Nelumbinis Plumula 10˜70; Sophorae Flavescentis Radix 150˜350; Artemisiae Annuae Herba 150˜350; Ginseng Radix Et Rhizoma 65˜265; Ophiopogonis Radix 150˜350; and Glycyrrhizae Radix Et Rhizoma 62˜265.