Herbal Respiratory Formulation Stability via Extract Ratio Control
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Solution Overview
Problem
Existing formulations comprising herbal agents like Hedera helix, Pelargonium sidoides, and Zingiber officinale face challenges in maintaining physical stability and ideal physical properties, such as taste, scent, color, and clarity, which are crucial for patient compliance and effectiveness in treating respiratory diseases.
Innovation Solution
A formulation comprising Hedera helix extract, Pelargonium sidoides extract, and Zingiber officinale extract, with Zingiber officinale content limited to less than 30% (preferably between 0.1% and 4% w/v), and specific weight ratios, combined with suitable excipients like sorbitol and eucalyptus, to enhance physical stability and patient compliance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If Zingiber officinale extract is added to enhance therapeutic effect, then the treatment effectiveness improves, but the physical stability and clarity of the formulation deteriorates
Solution Approach 1:
The patent applies parameter changes by precisely controlling the concentration of Zingiber officinale extract within 0.1-4% w/v and setting specific weight ratios between extracts (Hedera helix: Pelargonium sidoides: Zingiber officinale = 1:(2-5):(0.5-2)) to maintain both therapeutic effectiveness and physical stability. This quantitative optimization resolves the contradiction by finding the optimal parameter range where both benefits coexist.
2Reliability
If higher concentration of herbal extracts is used to improve therapeutic effect, then the treatment effectiveness improves, but the formulation stability and patient compliance deteriorates
Solution Approach 1:
The patent optimizes extract concentrations to specific ranges (Hedera helix: 0.1-20% w/v, Pelargonium sidoides: 0.1-30% w/v, Zingiber officinale: 0.1-4% w/v) to achieve therapeutic effectiveness while maintaining acceptable physical properties for patient compliance. This prevents excessive bitterness and maintains clarity.
Solution Approach 2:
The patent introduces excipients as intermediary substances to mediate between the herbal extracts and the final formulation. These excipients help mask bitter tastes, improve solubility, and maintain physical stability, thereby enabling higher extract concentrations without compromising patient compliance.
3Reliability
If multiple herbal extracts are combined to broaden therapeutic spectrum, then the treatment effectiveness improves, but the formulation complexity increases
Solution Approach 1:
The patent combines three complementary herbal extracts (Hedera helix for expectorant action, Pelargonium sidoides for immune modulation, and Zingiber officinale for anti-inflammatory effects) into a single integrated formulation. The specific weight ratios ensure synergistic effects while managing the complexity through defined proportions.
Solution Approach 2:
The patent manages formulation complexity by establishing specific concentration ranges and weight ratios for each component. This quantitative framework simplifies the manufacturing process and quality control despite the multi-component nature of the formulation.
Data Source
AI summary
The present invention is related to a formulation comprising Hedera helix, Pelargonium sidoides, and Zingiber officinale extracts to be used in the treatment, prevention of various respiratory diseases or alleviation and/or elimination of symptoms thereof and a method for preparing said formulation.