Herbo-lipid Composition for Chemotherapy Side Effect Mitigation
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Solution Overview
Problem
Chemotherapy for cancer induces adverse side effects such as inflammation, oxidative stress, and immune response reduction, leading to impaired quality of life in patients due to its inability to distinguish between cancer cells and normal cells.
Innovation Solution
A herbo-lipid composition comprising extracts of Padmak petals and stalks, Durva whole plant, and Ananta roots, combined with cow's ghee, which are blended and heated to create a thick viscous liquid, providing anti-inflammatory and immunomodulatory effects to alleviate chemotherapy-induced adverse effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If chemotherapy is used to treat cancer, then the primary tumour load and distant metastasis are reduced, but adverse side effects such as inflammation, nausea, vomiting, and immune response reduction occur
Solution Approach 1:
The patent introduces herbal extracts (Padmak, Durva, Ananta) as intermediary substances that mediate between the harmful chemotherapy agents and the patient's body. These herbal components act as protective intermediaries that reduce inflammation and oxidative stress while allowing chemotherapy to continue at effective doses
Solution Approach 2:
The patent creates a composite therapeutic approach by combining multiple herbal extracts (Padmak petals and stalks, Durva whole plant, Ananta roots) with specific lipid content (90-98 wt%). This composite formulation synergistically addresses multiple adverse effects simultaneously - inflammation, oxidative stress, and immune suppression - while preserving chemotherapy efficacy
2Reliability
If chemotherapy drugs are administered to kill cancer cells, then tumour growth is controlled, but normal dividing cells are also damaged leading to reduced quality of life
Solution Approach 1:
The patent converts the harmful oxidative stress and inflammation caused by chemotherapy into beneficial effects by introducing herbal antioxidants and anti-inflammatory compounds. The same pathological processes that cause damage are counteracted by opposite pharmacological actions from the herbal extracts, transforming the harmful environment into a protective one
Solution Approach 2:
The patent changes the biochemical parameters of the patient's body during chemotherapy by introducing herbal compounds that modify oxidative stress levels, inflammatory markers, and immune cell function. These parameter changes allow the body to tolerate chemotherapy better while maintaining its anti-cancer effectiveness
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The herbo-lipid composition effectively reduces inflammation, improves quality of life, and mitigates local adverse effects of radiotherapy and chemotherapy, enhancing overall well-being and metabolism in cancer patients.
Implementation Method 1
The herbo-lipid composition effectively reduces inflammation, improves quality of life, and mitigates local adverse effects of radiotherapy and chemotherapy
Implementation Method 2
The mixture is heated at a temperature in the range of 60° C. to 120° C. for a predetermined time to obtain the herbo-lipid composition in the form of thick viscous liquid
Data Source
AI summary
The present disclosure relates to a herbo-lipid composition for alleviating symptoms related to inflammation resulting into improved quality of life. The herbo-lipid composition comprises an extract of petals and stalks of Padmak, an extract of whole Durva plant, and decoction of roots of Ananta, which are processed in cow's ghee. The herbo-lipid composition of the present disclosure can be used internally for alleviating symptoms of inflammation mainly in erythematous skin rash. Its topical application is also beneficial in radiotherapy induced adverse effects like burning micturition, burning in vagina, dysuria, diarrhea and pain in lower abdomen in cervical cancer patient and stomatitis, and local burning in oral cancer patients. The composition also helps in reducing radiotherapy and chemotherapy induced adverse effects in various types of cancers when given orally.