Ointment Delivery TRIZ Cases

Short-half-life topical beta blockers with permeation enhancers target hemangiomas locally while limiting systemic exposure and side effects.

By reversibly disrupting the basement membrane, this patch broadens transdermal delivery to larger drugs with faster local or systemic uptake.

Biodegradable suramin hydrogels use sustained release to move chronic wounds beyond prolonged inflammation and support healing.

A patterned hydrogel on an electrospun nanoporous membrane enables localized, quantitative BMP or anticancer drug release while limiting side effects.

Ester-free crosslinking between multi-arm polymers and polyamino compounds creates hydrogels with long-term in vivo stability and radiopacity.

Decellularized amniotic membrane hydrogel preserves ECM proteins while removing cells, improving biocompatibility and scalability for tissue scaffolds.

A hydrogel with solid lipid anesthetic particles delivers burst and sustained postoperative pain relief in one injection, reducing opioid use.

A dendronized polyglycerol sulfate boosts SARS-CoV-2 inhibition while minimizing anticoagulant activity, enabling safer antiviral use.

An emulsion with hydrophobic and aqueous phases improves topical phenylbutyrate release, local concentration, and skin retention.

A topical patidegib composition inhibits hedgehog signaling to treat and prevent PTCH1-mutant BCC lesions with less invasive care.

Linear hydrogel formulations can provide thermosensitive gelation but weak sustained release; a biodegradable star polymer supports diffusion and self-degradation.

BPIFA2 peptides form hydrogels and nanofibrillar networks that inhibit bacterial growth and biofilms while supporting wound healing.

Conventional follicle transplantation can yield low efficiency; mesenchymal cell beads improve regeneration through controlled cell aggregation.

Modified CAHS proteins prevent polymerization and gel formation while preserving biological materials across a wide temperature range.

Active-substance beads wrapped in an appetizing gel mask repellent odors, helping animals voluntarily accept oral treatment.

Surface roughness helps adhesive hydrogels bond with hard and soft substrates in wet environments without catechol oxidation or harsh conditions.

Defined ranges of diclofenac, gabapentin, baclofen, and cyclobenzaprine combine topical treatment for neuropathic pain and inflammation.

This case uses reversible antibody–hyaluronic acid gelation to sustain local release, preserve activity, and limit systemic side effects.

This case shows how micelle-forming surfactants and solid adsorbents purify methacryloyl-gelatin for efficient hydrogel production.

Auxetic hydrogel patches match organ mechanics for stronger adherence.

A Montelukast topical emulsion uses carbomer and cellulose polymer to disperse particles under 50 microns for homogeneous delivery.

Cationic amphiphilic drugs induce lysosomal membrane permeabilization, releasing nucleic acids from endosomes while minimizing cytotoxicity.

A topical multi-kinase inhibitor composition targets VEGFR and FGFR receptors to reduce abnormal dermal blood vessel angiogenesis.

Plant extract blends in topical compositions resolve acne and rosacea symptoms while avoiding harsh side effects from conventional keratolytic agents.

A bio-dissolvable polymer marker impregnated with gadolinium provides high contrast during magnetic resonance imaging procedures.

Boronated polymers enable reversible drug delivery at acidic pH levels by forming stable nanoparticles with enhanced endosomal escape properties.

Composite material with macroporous gel stores therapeutic agents, eliminating expensive isolation procedures.

Microcapsules encapsulate benzoyl peroxide to control dissolution rates below 80% per hour, reducing skin irritation while maintaining therapeutic efficacy.

Heterocyclic transition metal complexes absorb high energy visible light in polymerized ophthalmic lenses.

An acidic compound with pKa less than 3 protonates nucleophilic groups in a polyether-polyester copolymer formulation to prevent polymer degradation.

Segmented filaments combine different active agents and release profiles in single units, resolving versatility versus complexity trade-offs.

A composite burn cream combines zinc oxide sulfanilamide and iodine to resolve the contradiction between high efficacy and skin irritation.

Cyclic compression via biphasic ferrogels mechanically stimulates injured muscle tissue to promote regeneration.

Photolithography generates shelf-stable photoresist patterned glass substrates for hydrogel cell culture.

A reducing agent mediates cross-linking between aminothiol and cyano groups, ensuring homogeneous cell encapsulation despite rapid polymerization risks.

Combining Fmoc-FF dipeptides with Fmoc-Phe amino acids via co-assembly overcomes limited mechanical properties in single-component hydrogels.

A multifunctional hydrogel combines gelatin, reduced graphene oxide, and activated yeast to create a conductive material with superior mechanical strength.

Methyl 4-[9-(6-aminopuryl)]-2(s)-hydroxybutyrate reduces inflammation and side effects associated with steroid treatments.

Controlled thiol-heteroaromatic crosslinking prevents non-uniform cell distribution caused by rapid polymerization.

Nano liquid composition containing curcumin overcomes low water solubility and poor stability to promote faster wound healing without systemic toxicity.

Cyclodextrin inclusion complexes encapsulate montelukast to shield it from light-induced degradation, enabling stable semi-solid topical delivery.

A dual-transition hydrogel prevents syringe clogging by maintaining solubility during injection.

A herbo-lipid composition blends Padmak, Durva, and Ananta extracts in cow's ghee to deliver anti-inflammatory effects.