Patterned Hydrogel Nanoporous Membrane for Local Drug Release
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Solution Overview
Problem
Current methods for delivering bone morphogenetic proteins and anticancer drugs face challenges with non-quantitative and localized delivery, leading to undesired tissue growth and significant side effects.
Innovation Solution
A method involving patterning a hydrogel with target compounds onto an electrospun nanoporous membrane, using a micromold process to create a hemispherical hydrogel pattern, which controls release based on hydrogel concentration, utilizing gelatin methacryloyl, hyaluronic acid, and Na-alginate, and cross-linking with UV light.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If carriers or nanoparticles are synthesized in a polymeric-based fibrous membrane and attached by injection, then delivery of bone morphogenetic proteins is achieved, but the delivery is not quantitative and causes undesired tissue growth
Solution Approach 1:
The patent applies local quality by creating spatially distinct regions within the hydrogel matrix that have different properties. Specifically, it creates a core region with high bone morphogenetic protein concentration for quantitative delivery, and a peripheral region with lower concentration that prevents undesired tissue growth. This is achieved through controlled phase separation or compositional gradients during hydrogel formation.
Solution Approach 2:
The patent segments the hydrogel into distinct functional zones: a core region for high-density protein delivery and a peripheral region for controlled release and preventing unwanted growth. This segmentation allows each region to perform its specific function optimally, achieving both quantitative delivery and preventing harmful effects.
2Manufacturing precision
If hydrogel is used for delivering bone morphogenetic proteins and anticancer drugs, then localized delivery is achieved, but side effects occur and quantitative control is limited
Solution Approach 1:
The patent creates local quality variations within the hydrogel by incorporating different concentrations of bone morphogenetic proteins and anticancer drugs in specific regions. The core region contains high concentrations for effective delivery, while the peripheral region contains lower concentrations that minimize side effects, achieving precise localized control.
Solution Approach 2:
The patent utilizes parameter changes in hydrogel composition, specifically varying the concentration of bone morphogenetic proteins and anticancer drugs across different regions. By controlling these concentration parameters during hydrogel formation, the patent achieves quantitative control over delivery while minimizing harmful side effects through gradient distribution.
3Quantity of substance
If conventional delivery methods are used, then treatment is administered, but quantitative and localized delivery cannot be achieved simultaneously
Solution Approach 1:
The patent segments the delivery system into distinct spatial regions within the hydrogel, with the core region providing quantitative delivery of bone morphogenetic proteins and the peripheral region providing localized control. This segmentation enables both quantitative and localized delivery to occur simultaneously in different zones of the same system.
Solution Approach 2:
The patent transitions from conventional uniform delivery to a multi-dimensional concentration gradient within the hydrogel. By creating a radial or spatial gradient of drug and protein concentrations, the system achieves both quantitative delivery (in the core) and localized control (at the periphery) simultaneously, adding a dimensional aspect to the delivery control.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables quantitative and localized delivery of bone morphogenetic proteins and anticancer drugs, reducing side effects and enhancing treatment efficacy.
Implementation Method 1
patterning a hemispherical hydrogel onto the electrospun nanoporous membrane by crosslinking the hydrogel onto the electrospun nanoporous membrane
Implementation Method 2
cross-linking the hydrogel onto the electrospun nanoporous membrane
Data Source
AI summary
Provided is a method of controlling local release of target compounds by patterning a hydrogel carrying a bone morphogenetic protein or anticancer drug as the target compounds onto an electrospun nanoporous membrane. The hydrogel is capable of controlling local release of the bone morphogenetic protein or anticancer drug as a carrier of the bone morphogenetic protein or anticancer. And the electrospun nanoporous membrane performs a basic function of the membrane of preventing infiltration of connective tissue. Thus, there is an advantage in that the hydrogel patterned nanoporous membrane can facilitate generation of controlled bone in a local region and degradation of cancer in a local region.