Hydrazide Compound Composition for Stable Agricultural Bactericidal Activity
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Solution Overview
Problem
Existing fungicides face challenges in providing high efficacy against plant pathogens while minimizing drug resistance, chemical damage to plants and soil, and toxicity to livestock and fish, and require an industrially advantageous synthesis process.
Innovation Solution
Development of a hydrazide compound with specific structural formulas (Z-1) and its salts, which exhibit excellent fungicidal activity and can be synthesized using a method involving the reaction of compounds (im-1) and (im-2) in the presence of an acid scavenger, or compounds (im-5) and (im-6) with a condensing agent or acid scavenger, depending on the substituent U1.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing fungicides are used to achieve high efficacy against plant pathogens, then fungicidal activity is improved, but drug resistance, chemical damage to plants and soil pollution, and toxicity to livestock and fish worsen
Solution Approach 1:
The patent introduces a novel hydrazide compound structure with specific molecular parameters (formula (I) with defined substituents R1-R7 and structural components U1-U6, Het1-Het6) that fundamentally changes the chemical parameters of fungicides. This structural innovation provides high fungicidal activity while reducing harmful effects through optimized molecular design, addressing the contradiction between efficacy and safety
Solution Approach 2:
The patent creates a composite chemical structure combining hydrazide core with specific heterocyclic rings and substituent groups. This composite molecular architecture integrates multiple functional components that work synergistically to achieve both high fungicidal activity and reduced environmental toxicity, resolving the contradiction between effectiveness and harm reduction
2Ease of manufacture
If conventional synthesis methods are used for fungicides, then production is simplified, but industrial advantage and synthesis efficiency worsen
Solution Approach 1:
The patent divides the synthesis process into distinct modular stages: preparing compounds of formula (im-1) and (im-2), then condensing them to form the final hydrazide compound. This segmented approach with clearly defined intermediates and reaction steps facilitates industrial-scale production while maintaining efficiency and quality control
Solution Approach 2:
The patent optimizes synthesis parameters including using specific acid scavengers or condensing agents, controlling reaction conditions, and selecting appropriate solvents. These parameter optimizations transform the synthesis process into an industrially advantageous method that balances ease of manufacture with high productivity
Data Source
AI summary
In the present invention, a compound represent by formula Z-I has excellent bactericidal activity and has excellent stability. (In the formula: Q1 represents a phenyl group, or the like; Q2 represents a phenyl group, or the like; partial structure Het represents a six-membered heteroaryl ring, or the like; Za represents an oxygen atom, or the like; T represents a partial structure (T-1) or (T-2); Z represents an oxygen atom, or the like; R6 represent a hydrogen atom, a C1-6 alkyl group, or the like; Zb represents a C1-6 alkoxy group, or the like; R4 represents a hydrogen atom, or the like; R5 represents a hydrogen atom, or the like; n represents any integer from 1 to 3; and R7 represents a hydrogen atom, a C1-6 alkyl group, or the like.)