Hyaluronan-Methylcellulose Hydrogel for Injectable Tissue Adhesion Control
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current anti-adhesive barriers for reducing tissue adhesion after surgery are difficult to deliver and do not sufficiently reduce or limit tissue adhesion, leading to post-surgical complications such as chronic pain.
Innovation Solution
A hydrogel composition comprising 2% to 6% by weight hyaluronan and 3% to 18% by weight methylcellulose, with a combined total amount of 8 to 24% by weight and a hyaluronan to methylcellulose ratio of 1:1 to 1:5, is administered to the tissue to reduce or limit tissue adhesion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current anti-adhesive barriers are used, then tissue adhesion is reduced to some extent, but the barriers are difficult to deliver and do not sufficiently reduce tissue adhesion
Solution Approach 1:
The patent changes the physical and chemical parameters of the anti-adhesive barrier by formulating a hydrogel composition with specific concentrations of hyaluronan (2-6%) and methylcellulose (3-18%), creating a material that is both deliverable and effective at reducing tissue adhesion
Solution Approach 2:
The patent uses a composite hydrogel material combining hyaluronan and methylcellulose in specific ratios (1:1 to 1:5 w/w) to achieve properties that neither component alone could provide, resulting in a barrier that is both easy to deliver and highly effective
2Reliability
If higher concentrations of hyaluronan and methylcellulose are used, then anti-adhesive efficacy is improved, but the viscosity and deliverability of the composition may be compromised
Solution Approach 1:
The patent optimizes the concentration parameters of hyaluronan (2-6%) and methylcellulose (3-18%) to achieve the right balance between anti-adhesive efficacy and deliverability, ensuring the composition remains injectable while providing sufficient barrier function
Solution Approach 2:
The patent creates local quality variations in the hydrogel composition by using specific molecular weight ranges for hyaluronan (100,000-3,000,000 g/mol) and methylcellulose (10,000-500,000 g/mol) to achieve optimal performance at the tissue interface while maintaining overall deliverability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The hydrogel composition effectively limits tissue adhesion for a period of greater than or equal to 1 week, 2 weeks, 3 weeks, 4 weeks, 5 weeks, 6 weeks, 7 weeks, or 8 weeks, providing significant reduction in fibrosis and associated post-surgical complications.
Implementation Method 1
Anti-adhesive barriers can be applied to limit tissue adhesion
Implementation Method 2
a hydrogel composition that includes: 2% to 6% (or more particularly between 3 and 5%) by weight hyaluronan, and 3% to 18% (or more particularly between 8 and 10%) by weight methylcellulose
Data Source
AI summary
A method of reducing or limiting tissue adhesion comprises contacting the tissue with an effective amount of a hydrogel composition comprising: 2% to 6% by weight hyaluronan, and 3% to 18% by weight methylcellulose, wherein the combined total amount of hyaluronan and methylcellulose in the hydrogel is between 8 and 24% by weight; and wherein the ratio of hyaluronan:methylcellulose is between 1:1 and 1:5 w/w. The hydrogel composition and may be used to reduce or limit tissue adhesion that is correlated with surgery, and may be used in surgeries wherein the surgery is performed through a small incision or opening.