Surgical Drugs TRIZ Cases

Injected biodegradable cryoprotectants protect the neurovascular bundle during prostate cryosurgery while preserving tissue viability.

Dual ionic and covalent crosslinks stabilize alginic acid gels against chelating agents while preserving permeability and biocompatibility.

An EpCAM-targeted NIR probe helps surgeons distinguish GI tumors and positive lymph nodes from fibrosis or necrosis during resection.

PEG 3350, sodium docusate, and simethicone combine in a GRAS-listed solution to reduce stool residue and foam during endoscopy.

Injecting a biodegradable, non-toxic cryoprotective composition into the periprostatic space helps preserve nerves during prostate cryosurgery.

A hyaluronan-methylcellulose hydrogel forms a localized mass to limit adhesion and fibrosis after surgery.

This case uses defined polymer ratios to form a deliverable barrier that limits tissue adhesion and fibrosis after surgery.

A biomaterial preservation composition uses microbubbles with controlled gas compositions to maintain cell viability.

SEK-1005 cyclic peptide induces angiogenesis in subcutaneous tissue, resolving low engraftment rates caused by insufficient oxygen supply.

Replaces high-potassium solutions with esmolol and adenosine to prevent intracellular sodium and calcium overload during cardiac arrest.

Amino acid composition reduces fat infiltration in muscle tissue, addressing inadequate pharmacological agents for treating muscle atrophy.

A leukocyte apheresis column removes neutrophils from patient blood to suppress surgical site infections during digestive system operations.

A handheld plasma delivery device seals annular tears in the vertebral disc to contain the nucleus pulposus.

A stem cell selection method using IFN-gamma induced HLA-Class I expression and CD46 levels to identify suitable allogeneic populations.

Plastically compacting scaffold fiber gels overcomes slow cell-based remodelling to rapidly produce functional tissue implants.

A buoy suspension fractionation system uses a tuned density buoy with an inclined guide surface to separate blood components via centrifugation.

Co-extruded gellan and hyaluronic acid fibres form a compact, bioadhesive matrix that absorbs exudate while maintaining moisture balance.

PCBAA zwitterionic hydrogel prevents fibrin matrix formation and fibroblast adhesion, eliminating recurrent adhesions after abdominal surgery.

A bioresorbable polymer forms through polyaddition of caprolactone and diisocyanate to enable tailored degradation profiles.

Pafolacianine binds folate receptors on cancer cells to emit near-infrared fluorescence, resolving incomplete resection caused by poor lesion visibility.

Carbazole derivatives act as chemo-attractants to redirect fibrocytes from vital organs, reducing collagen deposition while sparing healthy tissue repair.

Shape-memory cryogel scaffolds resolve the trade-off between structural support and patient trauma by enabling minimally invasive injection.

Stromal vascular fraction cells enhance transplant vascularization by eliminating the need for pre-grown microvascular beds.

Crosslinkable albumin forms a hydrogel depot that maintains effective drug concentrations at the target site while minimizing systemic side effects.