Microbubble Biomaterial Preservation Composition
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Solution Overview
Problem
The preservation of organs obtained from cadaveric bodies for transplantation is challenging due to variability in the time since death, leading to organ damage during reperfusion and inconsistent quality post-preservation.
Innovation Solution
A biomaterial preservation composition and method utilizing microbubbles, specifically fine bubbles with controlled gas compositions such as CO, H2S, and O2, to maintain cell viability and prevent damage during preservation and reperfusion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of stationary object
If organs are preserved using conventional methods, then preservation time can be extended, but organ damage during reperfusion increases and quality consistency deteriorates
Solution Approach 1:
The patent applies parameter changes by controlling the gas composition within microbubbles (specific ratios of CO, H2S, and O2) and adjusting microbubble concentration in the preservation solution. These parameter changes create a controlled chemical environment that maintains organ quality consistency while extending preservation time, directly resolving the technical contradiction between prolonged preservation and quality reliability.
2Duration of action of stationary object
If preservation time is extended for cadaveric organs, then transplantation availability increases, but reperfusion damage worsens
Solution Approach 1:
The patent implements preliminary action by pre-treating organs with microbubble-containing preservation solution before transplantation. The microbubbles with controlled gas composition (CO, H2S, O2) are introduced into the organ tissue in advance, creating protective effects that prevent reperfusion damage when the organ is later transplanted and blood flow is restored, thus enabling extended preservation without increasing damage.
Solution Approach 2:
The patent converts the potentially harmful effect of extended preservation (which normally leads to degradation) into a benefit by using microbubbles to create a protective environment. The microbubbles with specific gas compositions transform the preservation period from a damaging process into a protective one, allowing long-term preservation while preventing reperfusion injury.
Data Source
AI summary
The present invention provides a composition that can preserve biomaterials. The biomaterial preservation composition of the present invention includes a micro bubble.