Injectable Hyaluronan-Methylcellulose Hydrogel for Tissue Adhesion Control
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Solution Overview
Problem
Current anti-adhesive barriers are difficult to deliver and do not sufficiently reduce or limit tissue adhesion, leading to post-surgical complications such as chronic pain and complications in subsequent surgeries.
Innovation Solution
A hydrogel composition comprising 2-6% hyaluronan and 3-18% methylcellulose, with a combined ratio of 1:1 to 1:5, is administered to tissues during or after surgery, providing an injectable solution that limits tissue adhesion for up to 8 weeks.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current anti-adhesive barriers are used, then tissue adhesion is limited to some extent, but the barriers are difficult to deliver and do not sufficiently reduce tissue adhesion
Solution Approach 1:
The patent changes the physical state and concentration parameters of the hydrogel components. By formulating a low-viscosity solution with specific concentrations of hyaluronan (0.1-5% w/v) and methylcellulose (0.1-10% w/v), the composition becomes easily injectable through small-gauge needles while maintaining effective anti-adhesive properties upon delivery
Solution Approach 2:
The patent combines two biocompatible polymers - hyaluronan and methylcellulose - in specific ratios to create a composite hydrogel composition. This composite approach provides both ease of delivery (due to low viscosity) and sufficient efficacy (through synergistic interaction of the two polymers in forming anti-adhesive barriers)
2Object-affected harmful factors
If anti-adhesive barriers are applied to limit tissue adhesion, then post-surgical complications are reduced, but the barriers are difficult to deliver
Solution Approach 1:
The patent optimizes viscosity parameters by controlling polymer concentrations and molecular weights, enabling the composition to flow easily through small-gauge needles during delivery while maintaining sufficient viscosity and structural integrity after injection to form effective anti-adhesive barriers that prevent post-surgical complications
Solution Approach 2:
The patent utilizes the fluid dynamics properties of the low-viscosity hydrogel solution to enable easy injection through small-gauge needles. The composition's rheological characteristics allow it to be delivered hydraulically through minimally invasive routes while maintaining stability and efficacy at the target site
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The hydrogel effectively reduces tissue adhesion by forming a localized mass, limiting fibrosis and adhesion for an extended period, thereby reducing chronic pain and complications in surgeries involving small incisions.
Implementation Method 1
A hydrogel composition comprising 2-6% hyaluronan and 3-18% methylcellulose, with a combined ratio of 1:1 to 1:5, is administered to tissues during or after surgery, providing an injectable solution that limits tissue adhesion for up to 8 weeks.
Data Source
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AI summary
A method of reducing or limiting tissue adhesion comprises contacting the tissue with an effective amount of a hydrogel composition comprising: 2% to 6% by weight hyaluronan, and 3% to 18% by weight methylcellulose, wherein the combined total amount of hyaluronan and methylcellulose in the hydrogel is between 8 and 24% by weight; and wherein the ratio of hyaluronan:methylcellulose is between 1:1 and 1:5 w/w. The hydrogel composition and may be used to reduce or limit tissue adhesion that is correlated with surgery, and may be used in surgeries wherein the surgery is performed through a small incision or opening.