Imino Compounds with 2-Chloropyrimidin-5-yl Substituent for Pest Control
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Solution Overview
Problem
Current pesticidal compounds have unsatisfactory activity against difficult-to-control insects and acarid pests, leading to a need for new agents that can effectively combat these invertebrate pests.
Innovation Solution
Development of imino compounds of a specific formula (I) and their stereoisomers, tautomers, and salts, which are used in agricultural and veterinary compositions to combat invertebrate pests by applying them to plants, soil, or animals, thereby protecting crops and animal health from infestation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing pesticidal compounds are used, then basic pest control is achieved, but pesticidal activity against difficult-to-control insects and acarid pests is insufficient
Solution Approach 1:
The patent modifies the chemical structure of pesticidal compounds by changing specific parameters: introducing a 2-chloropyrimidin-5-yl substituent at position R1, selecting specific heterocyclic radicals for R2, and configuring the T ring system. These structural parameter changes result in compounds with improved pesticidal activity, particularly against difficult-to-control insects and acarid pests, while maintaining the core functional architecture needed for pest control effectiveness across different pest types.
2Reliability
If new pesticidal compounds are developed to combat resistant pests, then pesticidal activity is improved, but the complexity of compound structure increases
Solution Approach 1:
The patent applies segmentation by dividing the pesticidal compound into distinct functional modules: a core T ring system (5- or 6-membered heterocyclic ring with specific heteroatoms), a 2-chloropyrimidin-5-yl substituent group, and variable R1/R2 radical groups. This modular segmentation allows for systematic optimization of pesticidal activity while managing molecular complexity through structured assembly of functional units rather than random structural elaboration.
Solution Approach 2:
The patent designs compounds with universal applicability against multiple pest types (insects, acarid pests, nematode pests) by incorporating a versatile core structure that can interact with diverse pest targets. The T ring system with specific heteroatom composition and the 2-chloropyrimidin-5-yl substituent create a multi-functional molecule capable of binding to different pest enzymes or receptors, achieving broad-spectrum efficacy without proportionally increasing structural complexity.
Data Source
AI summary
Provided herein are imino compounds of formula Iand stereoisomers, tautomers and salts thereof. Further provided herein are agricultural and veterinary compositions including the compounds. Also provided herein are methods related to the use of these compounds, and the stereoisomers, tautomers and/or salts thereof, for combating invertebrate pests. Further provided herein are methods for combating invertebrate pests, wherein the methods include applying such compounds, steroisomers, tautomers, and salts.