Injectable Bone Adhesive Composition for Strong Fracture Fixation
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Solution Overview
Problem
Current bone adhesives lack sufficient mechanical and adhesive strength, and existing metallic fixation devices for comminuted fractures are costly and require secondary surgeries, while minimally invasive surgery necessitates injectable adhesives for bone regeneration.
Innovation Solution
An injectable bone adhesive composed of amino-functionalized polyhydroxyl polyethylene glycolylated polyglyceryl sebacate (PEGS-NH2) and phosphorylated polyglutamic acid (PGA-P) with calcium phosphate salts, crosslinked by EDC/NHS, providing high mechanical strength, adhesion, and osteogenic properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If metallic internal fixation devices are used for comminuted fractures, then fixation reliability is improved, but surgical complexity and cost increase, and secondary surgeries are required
Solution Approach 1:
The patent extracts the essential function of fixation from complex metallic devices and concentrates it into a simple injectable adhesive composition. The adhesive contains polymers, calcium phosphate salts, and crosslinking agents that provide fixation reliability without requiring complex surgical procedures or secondary surgeries.
Solution Approach 2:
The patent replaces the mechanical fixation system (screws, plates, rods) with a chemical adhesive system. The adhesive cures in situ to bond bone fragments, substituting mechanical fastening with chemical bonding that achieves reliable fixation without surgical complexity.
2Ease of operation
If conventional bone adhesives are used, then ease of operation is improved, but mechanical strength and adhesion strength are insufficient
Solution Approach 1:
The patent creates a composite adhesive material combining organic polymers (first and second polymers with different functions), inorganic calcium phosphate salts for strength and osteoconductivity, and crosslinking agents. This composite structure achieves both high mechanical strength and ease of injection application.
Solution Approach 2:
The patent optimizes parameters including polymer molecular weight (10,000-1,000,000 Da), calcium phosphate salt content (10-90 wt%), and crosslinking agent ratios to achieve the desired balance between mechanical strength and injectability. The curing time and final strength are controlled by adjusting these compositional parameters.
3Object-affected harmful factors
If injectable bone adhesive is used for minimally invasive surgery, then surgical trauma is reduced, but adhesion strength and mechanical properties deteriorate
Solution Approach 1:
The patent provides local quality enhancement at the bone interface through the adhesive formulation. The calcium phosphate salts concentrate at the bone surface to create strong local bonding, while the polymer matrix provides bulk mechanical properties. This localized optimization achieves high adhesion strength without requiring invasive surgery.
Solution Approach 2:
The adhesive acts as an intermediary material between bone fragments, containing calcium phosphate salts that chemically interact with bone mineral surfaces to enhance adhesion. The polymer matrix serves as a mediator that transmits mechanical loads while the calcium phosphate provides chemical bonding to the bone, achieving strong adhesion through minimal invasion.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The adhesive exhibits superior mechanical properties, strong adhesion to bone tissue, and promotes bone regeneration, suitable for fracture repair with minimal invasiveness and adjustable curing time.
Implementation Method 1
The first polymer and the second polymer are crosslinked via amide bond
Implementation Method 2
crosslinked by EDC/NHS
Implementation Method 3
The electrostatic interaction between phosphate groups and carboxyl groups with calcium ions yields a bone adhesive precursor solution with a certain viscosity
Data Source
AI summary
An injectable bone, a preparation method and use thereof are provided. The injectable bone adhesive has the following components: (c1) an organic component comprising: a first polymer and a second polymer; and (c2) an inorganic component comprising calcium phosphate salts and derivatives thereof. The injectable bone adhesive exhibits outstanding bone adhesion strength and excellent mechanical properties, can closely adhere to complex-shaped bone fragments in comminuted fractures to ensure stable fixation during fracture repair. Additionally, it possesses osteogenic capacity to promote fracture healing.