Biodegradable Injectable Paste With Crosslinked Hydrogel Rheology
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Solution Overview
Problem
Existing technologies face challenges in developing effective and biocompatible hydrogels that maintain mechanical strength and balance viscosity and elasticity, particularly for applications requiring load-bearing properties and avoiding early dissolution.
Innovation Solution
A biodegradable injectable paste composition comprising at least two backbone polymers, a diglycidyl ether monomer, an active ingredient, and a carrier, with an adhesive polymer having a single-helix structure, allowing for a single-syringe application and maintaining a balance between viscosity and elasticity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If natural compounds such as collagen, fibrin, and hyaluronic acid are used as main chains to improve biocompatibility, then biocompatibility is improved, but ease of deformation and engineering manipulation deteriorate
Solution Approach 1:
The patent uses composite materials by combining natural polymers (collagen, fibrin, hyaluronic acid) with synthetic crosslinking agents (genipin, glutaraldehyde, EDC/NHS). This composite approach maintains the biocompatibility of natural compounds while adding the mechanical strength and processability needed for engineering manipulation.
2Ease of manufacture
If gelatin is used as main chain to improve ease of processing, then ease of processing is improved, but mechanical strength deteriorates
Solution Approach 1:
Gelatin is combined with crosslinking agents (genipin, glutaraldehyde, or EDC/NHS) to form a composite hydrogel system. The gelatin provides ease of processing and biocompatibility, while the crosslinking agents create a three-dimensional network that significantly enhances mechanical strength.
Solution Approach 2:
The patent changes the physical and chemical parameters of gelatin through crosslinking. By controlling crosslinking density, pH, temperature, and concentration, the mechanical properties of gelatin hydrogels are significantly improved while maintaining their processing advantages.
3Reliability
If hydrogels are used to improve biocompatibility, then biocompatibility is improved, but mechanical properties deteriorate
Solution Approach 1:
The patent creates composite hydrogels by integrating natural polymers with crosslinking agents. This composite structure maintains the high water content and biocompatibility characteristic of hydrogels while developing a three-dimensional network that provides sufficient mechanical strength for load-bearing applications.
Solution Approach 2:
The patent applies local quality by creating regions of different crosslinking density within the hydrogel. Areas requiring higher mechanical strength have increased crosslinking density, while other areas maintain higher water content for biocompatibility, achieving spatial optimization of properties.
4Reliability
If hydrogels are used to improve biocompatibility, then biocompatibility is improved, but tensile strength deteriorates
Solution Approach 1:
The patent employs composite material strategies by combining natural polymers with various crosslinking mechanisms. The crosslinked network structure distributes tensile loads more effectively throughout the hydrogel matrix, significantly improving tensile strength while preserving the biocompatible natural polymer backbone.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The biodegradable injectable paste offers biocompatibility, tackiness, and a balanced viscosity-elasticity, suitable for applications such as hemostatic agents, bone fillers, wound dressings, and tissue repair materials, with improved mechanical properties and biodegradability.
Implementation Method 1
Hyaluronic acid has a structure represented by Formula 1 below and can form hydrogels with various physical properties by covalent bonding
Implementation Method 2
Hydrogel is a three-dimensional structure composed of a network of hydrophilic molecules, and most of the components thereof are made of water
Data Source
AI summary
The present invention relates to a paste composition, a biodegradable injectable paste, and a method for producing the same. According to the present invention, the paste composition may offer the convenience of being applied to the application site using one syringe without the need to mix using two syringes immediately before use, by providing a crosslinked hydrogel as a paste phase, as well as biocompatibility, tackiness, and the balance between viscosity and elasticity, and thus is suitable for use in applications, including hemostatic agents, bone fillers, wound dressings, drug carriers, tissue repair materials, skin soothing agents, moisturizing agents, anti-inflammatory agents, and anti-atopic agents.