Ion Carpet SID Layout for Simpler Product Ion Collection
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Solution Overview
Problem
Existing surface-induced dissociation (SID) devices for mass spectrometry have limitations such as non-optimal product ion collection efficiency, complex tuning requirements, and usability challenges, particularly for non-experts, which hinder their application in online LC-MS separations and wide-range user compatibility.
Innovation Solution
A device with a tilted surface ion carpet (TSIC) and an angled deflector lens, utilizing a DC-only ion carpet with resistively coupled concentric rings and a semicircular deflector, simplifies ion guidance and focusing, reducing the number of independent voltages needed for operation, making it more intuitive and efficient.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If traditional SID devices use multiple independent DC lenses for ion guidance, then ion collection efficiency can be optimized, but device complexity and tuning requirements increase significantly
Solution Approach 1:
The patent combines multiple independent DC lenses into a single ion carpet component with multiple concentric rings. These rings are resistively coupled to create a voltage gradient, merging what were previously separate voltage control systems into one integrated structure. This reduces the number of independent voltages from multiple (in traditional devices) to just two (applied at opposite edges of the ion carpet), thereby reducing device complexity while maintaining ion collection efficiency.
Solution Approach 2:
The ion carpet is segmented into multiple concentric rings that are resistively coupled. This segmentation allows the creation of a continuous voltage gradient across the ion carpet without requiring independent control of each segment. The resistive coupling between adjacent rings creates intermediate voltages automatically, enabling efficient ion guidance through a simplified two-voltage system.
2Manufacturing precision
If traditional SID devices use multiple independently-controlled DC lenses, then ion focusing can be optimized, but ease of operation decreases due to complex tuning requirements
Solution Approach 1:
By merging multiple independently-controlled lenses into a single ion carpet with resistively coupled rings, the system reduces the number of independent tuning parameters from multiple to just two. This dramatically simplifies operation while maintaining ion focusing precision through the continuous voltage gradient established across the concentric rings.
3Productivity
If SID devices are designed with complex ion guidance systems, then ion collection efficiency improves, but adaptability to different instruments decreases
Solution Approach 1:
The ion carpet design with resistively coupled concentric rings creates a universal ion guidance component that can be adapted to different mass spectrometry instruments. The simplified two-voltage system and integrated structure make it easier to implement across various platforms (Q-TOF, Orbitrap, FT-ICR, etc.) while maintaining effective ion collection, thereby improving instrument compatibility and versatility.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The TSIC device enhances ion collection efficiency, reduces tuning complexity, and improves usability, allowing for robust and consistent results across various instruments, especially with limited sample quantities, while maintaining high sensitivity and adaptability for both high and low m/z ions.
Implementation Method 1
an ion carpet having applied electrical properties configured to guide product ions resulting from collision with the collision surface to a post-SID region
Implementation Method 2
a deflector configured to guide precursor ions from a pre-SID region to the collision surface
Data Source
AI summary
Devices and methods for surface-induced dissociation (SID) are disclosed. In one aspect, a device for SID is disclosed which, in one embodiment includes a collision surface, a deflector configured to guide precursor ions from a pre-SID region to the collision surface to cause SID, and an ion carpet having applied electrical properties configured to guide product ions resulting from collision with the collision surface to a post-SID region. In another aspect, a method for SID is disclosed which, in one embodiment includes guiding, by a deflector, precursor ions from a pre-SID region to a collision surface to cause SID, and guiding, by an ion carpet having selected applied electrical properties, product ions resulting from collision with the collision surface to a post-SID region.