Antiviral Composition Using Juncus acutus Extract

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Solution Overview

Problem

Current antiviral medications for viral infections such as herpes labialis, herpes zoster, and HIV are either ineffective or cause significant side effects, with a lack of well-tolerated and cost-effective solutions for prevention and treatment.

Innovation Solution

A composition combining extracts from Stinging Rush (Juncus acutus), white willow (Salix alba), rose (Rosa damascena), chamomile (Chamomilla matricaria), lavender (Lavandula angustifolia), and myrrh (Commiphora molmol) is used, which has been found to effectively prevent and treat viral infections by inhibiting virus replication and transcription without immunosuppressive effects.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional antiviral medications are used to treat viral infections, then viral infection control is achieved, but significant side effects occur

Engineering Contradiction:
Improveantiviral effectivenessVSAvoidside effects
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical parameters by using natural plant extracts (Juncus acutus, Salix alba, Rosa damascena, Chamomilla matricaria, Lavandula angustifolia, Commiphora molmol) instead of synthetic nucleoside analogs. This parameter change maintains antiviral effectiveness while reducing harmful side effects through the different chemical composition and mechanism of action of natural extracts.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent creates a composite antiviral composition by combining multiple plant extracts in specific proportions. This composite approach leverages the synergistic effects of different natural substances to achieve effective viral inhibition while minimizing the side effects associated with single-agent conventional medications.

Inventive Principle:
Principle #40Composite materials

2Reliability

If conventional antiviral medications are used for viral infections, then infection treatment is provided, but the medications are expensive

Engineering Contradiction:
Improveantiviral treatment effectivenessVSAvoidcost
Core Design Contradiction:
ReliabilityVSQuantity of substance

Solution Approach 1:

The patent employs inexpensive natural plant extracts that can be produced cost-effectively. The plant materials used (Juncus acutus, Salix alba, Rosa damascena, Chamomilla matricaria, Lavandula angustifolia, Commiphora molmol) are readily available and can be extracted using conventional methods, providing an affordable alternative to expensive synthetic antivirals.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

3Reliability

If nucleoside analogs are used to control herpes simplex infections, then viral replication is inhibited, but the medications cause immunosuppressive effects

Engineering Contradiction:
Improveherpes infection controlVSAvoidimmunosuppression
Core Design Contradiction:
ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent extracts and utilizes specific active components from natural plants (such as flavonoids, phenolic compounds, and other bioactive substances from Juncus acutus and other species) that inhibit viral replication without the immunosuppressive properties of synthetic nucleoside analogs. This extraction of natural bioactives provides targeted antiviral action spares immune function.

Inventive Principle:
Principle #2Taking out (Extraction)

Data Source

PatentEP2792389B1Antiviral Pharmaceutical composition comprising an extract of Juncus acutus
Publication Date: 2019.09.18 GLOBAL HEALTH SOLUTIONS
  • EP2792389B1 patent drawingFigure 1
  • EP2792389B1 patent drawingFigure 2

AI summary

A pharmaceutical composition containing an extract of the plant genus *Prickly Rush* possesses antiviral properties. In addition to the *Prickly Rush* extract, the composition may contain at least one other plant genus selected from the group consisting of *White Willow*, *Rose*, *Chamomile*, *Lavender*, and *Myrrh*.