Antivirals TRIZ Cases

A combination therapy using auranofin, ouabain, emetine, niclosamide, and fluoxetine suppresses EV71 replication through synergistic activity.

Small-molecule entry inhibitors bind to the SARS-CoV-2 spike receptor binding domain interface to block viral attachment.

OZ418 ozonides suppress cytomegalovirus replication while reducing bone marrow and kidney toxicity associated with standard antiviral therapies.

Formula I compounds disrupt HBV capsid assembly to reduce viral load, overcoming drug resistance and tolerability issues in chronic infection treatment.

Covalent CDK7 inhibitors block host cell machinery to treat resistant herpesvirus and papillomavirus infections without triggering rapid drug resistance.

Modified cyclosporine analogues bind host cyclophilin A to inhibit viral replication while reducing immunosuppressive side effects.

Young barley grass composition increases regulatory T cells while suppressing excessive immune responses to prevent autoimmune diseases.

Small molecule compounds modulate hepatitis B core protein assembly to inhibit viral replication and reduce HBV DNA levels.

Alcohol extraction of mushroom mycelium reveals novel antiviral compounds that overcome the limited efficacy of traditional hot water methods.

A multi-herb composition binds to the viral spike protein and inhibits 3CL protease activity.

A traditional Chinese medicine prescription disperses lung qi and detoxicates using a composite herbal extract.

Ethyl acetate partitioning isolates a caffeine-free theabrownin tea fraction that treats idiopathic pulmonary fibrosis without conventional drug side effects.

Plasmonic gold nanoparticle colorimetric assays detect SARS-CoV-2 antigens, replacing bulky RT-PCR equipment with simple visual or spectral readouts.

A composite pharmaceutical formulation using Centella asiatica, Withania somnifera, and Andrographis paniculata extracts to inhibit viral replication.

Entinostat activates latent reservoirs while nelfinavir blocks viral replication, reducing chronic toxicity and drug resistance.

Segmented linear PEG branches attach to a core molecule, resolving polymerization control issues while extending blood residence time.

Modified nucleoside diphosphate prodrugs attach two covalently bound non-bioreversible lipophilic moieties to the terminal phosphate group.

Probiotic fermentation transforms herbal ingredients into a liquid preparation that enhances antiviral activity and digestibility.

Tannin-rich plant extracts neutralize surface viruses and block intracellular replication to resolve incomplete topical infection inhibition.

Dexmedetomidine reduces 28-day mortality by inhibiting hyperimmune responses and inflammatory pathways that drive acute respiratory distress syndrome.

A pharmaceutical composition using Panax ginseng cambium stem cells increases CD4+ T-cell counts to enhance immune function.

A pharmaceutical composition containing Juncus acutus extract inhibits viral replication and transcription.

Polyamine transport inhibitors deplete intracellular polyamine pools, blocking viral replication and overcoming host compensatory import mechanisms.

Cleaving the conjugated macromolecule at target sites activates RIG-I while preventing systemic inflammation and toxicity from ubiquitous receptor expression.

Targeting the GagPol-tRNA3 Lys-mLysRS complex reduces viral resistance and side effects while maintaining treatment effectiveness.

Recombinant interferon alpha 2 variants with specific amino acid substitutions enhance antiviral activity against viral pathogens.

Epigenetic modulators reactivate latent HIV-1 proviruses, enabling antiretroviral therapy to eliminate persistent viral reservoirs.

A multiple-component antiviral formulation combining curcumin, harmine, and isovanillin to inhibit SARS-CoV-2 replication.

Computational analysis of TCRβ CDR3 sequences diagnoses COVID-19 and predicts severity without complex laboratory infrastructure.

Merges immune stimulation with capsid disruption to reduce HBV DNA and HBsAg levels.

A tiered heating regimen elevates body temperature to enhance immune system function and expel viral loads.

Segmented Fab fragments link cytokines via disulfide bonds, improving tumor uptake and distribution while reducing systemic toxicity.

Minor spliceosome inhibitors block viral replication by disrupting minor intron-containing gene expression, addressing inadequate existing therapeutics.

Smyd2 and HDAC inhibitors disrupt transcriptional silencing to reactivate latent HIV, enabling antiviral agents to clear the persistent viral reservoir.

FDA-approved small-molecule drugs inhibit viral replication through Akt pathway suppression and p53 activation.

Benzimidazole compounds bind to CRRM RNA stem loops in SARS-CoV-2 replicase, inhibiting viral translation and reducing infection severity.

Selective extraction removes cyanogenic glycosides from elderberry and chokeberry extracts to ensure safe antiviral efficacy.

CD4+ T cells express granzyme B and perforin to kill tumor cells while avoiding graft versus host disease.

A spray-dried amorphous solid dispersion of TMC125 in a water-soluble polymer matrix.

Sanguisorba officinalis Linne extract powder inhibits viral 3CL protease and RdRp activity.

PIKfyve and serine protease inhibitor combinations block viral entry pathways, reducing infectivity and severity of coronavirus symptoms.

Water-extracted Melastoma malabathricum root composition inhibits coronavirus replication in cell assays.

A composite herbal extract eliminates influenza viruses from lung tissues using synergistic phytochemicals.

Optimized betulinic acid derivatives suppress viral replication across polymorphic strains, reducing drug resistance and treatment complexity.

Segmented synthesis of dipeptide heterocycles targets specific parasite stages, overcoming drug resistance and manufacturing complexity.

Combining formula compounds with existing agents reduces drug dosage and side effects while maintaining therapeutic efficacy.

In vitro activated T cells target JC virus to slow progressive multifocal leukoencephalopathy progression.