Probiotic Fermentation of Herbal Compound for ASF Treatment
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Solution Overview
Problem
Current methods for preventing and treating African swine fever (ASF) are inadequate, with no effective drugs or vaccines available, and traditional Chinese medicine compounds have shown promise when combined with modern preparation technologies.
Innovation Solution
A traditional Chinese medicine compound made from specific herbal ingredients is enhanced through a probiotic fermentation process involving Bacillus subtilis, Saccharomyces cerevisiae, Bifidobacterium, and Lactobacillus acidophilus, which improves the compound's antiviral effects and digestibility for pigs.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional Chinese medicine compounds are used to prevent and treat ASF, then antiviral effects are improved, but bioavailability and digestibility are insufficient
Solution Approach 1:
The patent applies probiotic fermentation to transform the traditional Chinese medicine compound, changing its physical and chemical parameters. The fermentation process converts complex herbal ingredients into more bioavailable forms, improving digestibility and absorption while preserving antiviral activity. This parameter transformation resolves the contradiction between maintaining antiviral efficacy and enhancing bioavailability.
Solution Approach 2:
The patent introduces probiotics as an intermediary substance that mediates between the traditional Chinese medicine compound and the pig's digestive system. The probiotics ferment the herbal ingredients, creating intermediate products that are more easily absorbed while maintaining therapeutic effects. This intermediary process bridges the gap between raw herbal materials and bioavailable active ingredients.
2Reliability
If complex preparation technologies are used to enhance TCM compounds, then antiviral effects are improved, but manufacturing complexity and cost increase
Solution Approach 1:
The patent employs self-service fermentation where probiotics naturally transform the TCM compound without requiring complex external processing equipment. The fermentation process occurs under controlled but simple conditions, allowing the system to self-process the herbal ingredients into bioavailable forms. This eliminates the need for sophisticated extraction and purification equipment while maintaining enhanced antiviral effects.
Solution Approach 2:
The fermentation process changes the physical and chemical parameters of the TCM compound in situ, transforming it directly into a more effective form without requiring complex separation, concentration, or purification steps. This parameter transformation approach simplifies manufacturing while improving antiviral efficacy.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The fermented traditional Chinese medicine compound demonstrates significant antiviral effects and improved bioavailability, effectively preventing and treating ASF in pigs without causing gastrointestinal discomfort, and is suitable for mass production due to its simplicity and low cost.
Implementation Method 1
A traditional Chinese medicine compound made from specific herbal ingredients is enhanced through a probiotic fermentation process involving Bacillus subtilis, Saccharomyces cerevisiae, Bifidobacterium, and Lactobacillus acidophilus, which improves the compound's antiviral effects and digestibility for pigs.
Data Source
AI summary
A traditional Chinese medicine compound for preventing and treating African swine fever, its efficiency enhancement process, and application are provided, which relate to the field of fermentation technologies of traditional Chinese medicine by probiotics. A formula with the most apparent preventive and therapeutic effect on ASFV is obtained by comparing various traditional Chinese medicine prescriptions and self-drafted formulas, and the formula is made from Codonopsis pilosula, Atractylodes macrocephala, Wolfiporia cocos, Auckiandialappa Lappa Decne., Terminalia chebula, Aconitum carmichaeli, Myristica fragrans, Cynanchum otophyllum, Dioscorea polystachya and Ziziphus jujuba. Based on the formula, fermentation treatment of multi probiotics is performed, Bacillus subtilis, Saccharomyces cerevisiae, Bifidobacterium and Lactobacillus acidophilus are inoculated for fermenting, and a liquid fermented mixture is mixed to obtain fermentation preparation. The traditional Chinese medicine compound has a definite therapeutic effect, reasonable compatibility, a wide range of materials, and a low price, which makes it easy to promote and apply.