Lactobacillus Composition for Bone Disease Treatment
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current treatments for bone diseases such as osteoporosis and bone fractures are associated with significant side effects and require prolonged use, with limited evidence supporting the effectiveness of combination therapies, highlighting a need for novel approaches to effectively prevent, treat, or relieve these conditions.
Innovation Solution
The use of Lactobacillus plantarum GKM3 and Lactobacillus paracasei GKS6 in pharmaceutical or edible compositions to increase blood calcium concentration, thereby addressing bone diseases by improving bone parameters like trabecular bone volume density, trabecular thickness, trabecular number, and bone mineral density, while reducing trabecular spacing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current osteoporosis medicines (anti-resorptive drugs, osteogenic drugs) are used to treat bone diseases, then bone remodeling can be targeted and bone mass density can be improved, but significant side effects occur and prolonged use is required
Solution Approach 1:
The patent introduces probiotics (specifically Lactobacillus strains) as an intermediary substance to mediate bone health improvement. Instead of using direct pharmaceutical agents that target bone cells and cause side effects, the probiotics work through the gut-bone axis, producing metabolites that indirectly promote bone formation and inhibit resorption, thereby achieving therapeutic effects without the harmful side effects of conventional drugs
Solution Approach 2:
The patent replaces the mechanical/pharmaceutical intervention system (drugs directly acting on bone tissue) with a biological system (probiotics acting through metabolic pathways). The probiotics substitute for conventional medication by producing bone-forming peptides and other metabolites that naturally regulate bone remodeling, eliminating the need for prolonged pharmaceutical use and associated side effects
2Reliability
If combination therapies are used for bone diseases, then potentially enhanced effectiveness may be achieved, but there is limited evidence supporting their effectiveness
Solution Approach 1:
The patent employs a composite probiotic formulation containing multiple Lactobacillus strains (L. plantarum GKM3, L. paracasei GKS6, and other strains) with complementary functions. Each strain contributes different beneficial metabolites and mechanisms, creating a synergistic composite that enhances overall effectiveness while providing substantial evidence through in vitro and in vivo studies, thereby overcoming the lack of evidence for combination approaches
3Reliability
If Lactobacillus-based compositions are used to treat bone diseases, then blood calcium concentration and bone parameters can be improved, but the mechanism of action is less understood compared to conventional drugs
Solution Approach 1:
The patent utilizes feedback mechanisms where probiotic metabolites (such as calcium-binding peptides and other signaling molecules) continuously regulate bone remodeling based on physiological needs. The system monitors bone health status and adjusts bone formation and resorption rates accordingly, creating a self-regulating biological feedback loop that improves bone parameters while maintaining physiological balance, thereby managing the complexity through natural regulatory pathways
Data Source
AI summary
The present invention discloses uses of treating, preventing or improving bone diseases by Lactobacillus or a composition including the Lactobacillus. The Lactobacillus and compositions can increase the blood calcium concentration, the trabecular bone volume density, the trabecular thickness, the trabecular number and the bone mineral density of a subject, and reduce trabecular spacing of the subject. Further, the present invention discloses a method for treating a subject diagnosed with a bone disease, through identifying the subject having the bone disease and administering to the subject an effective amount of a composition including at least one of Lactobacillus plantarum GKM3 and Lactobacillus paracasei GKS6, wherein the Lactobacillus plantarum GKM3 is deposited in China General Microbiological Culture Collection Center (CGMCC) with a deposition number of CGMCC 14565 on Aug. 25, 2017, and the Lactobacillus paracasei GKS6 is deposited in CGMCC with a deposition number of CGMCC 14566 on Aug. 25, 2017.