Lactobacillus paracasei Strain Enhances Polyamine Synthesis
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Solution Overview
Problem
Current methods fail to effectively promote polyamine synthesis in organisms, particularly in humans, as the ability to synthesize polyamines decreases with aging, and existing food and drinks may not adequately provide the desired physiological benefits.
Innovation Solution
A Lactobacillus paracasei strain (WON0604: FERM BP-11468) with polyamine production promoting activity, hepatic neutral fat reducing activity, and energy metabolism promoting activity is identified and used to enhance polyamine production and metabolic health, which can be administered through food or pharmaceutical compositions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If external polyamine administration is used, then polyamine levels can be maintained, but the natural synthesis ability of the organism is not improved and long-term effectiveness is limited
Solution Approach 1:
The Lactobacillus paracasei strain WON0604 enables the organism to produce polyamines itself through probiotic action in the intestine, rather than relying on continuous external administration. The strain converts dietary components into polyamines in situ, allowing the body to self-generate the necessary substances.
Solution Approach 2:
The probiotic strain acts as an intermediary between dietary components and the host organism's polyamine needs. It resides in the intestine and converts available nutrients into active polyamines that can be absorbed and utilized by the body, bridging the gap between external intake and internal synthesis requirements.
2Quantity of substance
If conventional food and drinks containing polyamine are consumed, then polyamine intake is increased, but the effectiveness is insufficient due to poor absorption and metabolism
Solution Approach 1:
The probiotic strain serves as a mediator that enhances the bioavailability of polyamines. Instead of relying on direct absorption of dietary polyamines (which has poor bioavailability), the strain processes dietary components locally in the intestine to generate polyamines that are more effectively absorbed and utilized by the host.
Solution Approach 2:
The invention replaces the mechanical/physical approach of simply consuming polyamine-containing foods with a biological system. The probiotic strain biologically converts dietary components into active polyamines through metabolic processes, achieving better physiological effects than direct intake alone.
3Productivity
If polyamine synthesis ability is activated through diet, then natural production is enhanced, but conventional diets lack the specific components needed for effective synthesis
Solution Approach 1:
The probiotic strain performs the synthesis work itself within the intestinal environment, utilizing components already present in conventional diets. It autonomously converts available nutrients into polyamines without requiring special dietary modifications or additional supplements.
Solution Approach 2:
The invention changes the metabolic parameters within the intestinal environment by introducing the probiotic strain. This alters the biochemical conditions to favor polyamine synthesis from dietary components, effectively transforming ordinary diet into a source of active polyamines through biological parameter changes.
Data Source
AI summary
The present disclosure relates to a Lactobacillus paracasei strain having polyamine production promoting activity in an organism, as well as its application and relevant technologies. The present disclosure also relates to the use of the Lactobacillus paracasei strain to promote polyamine production in humans and animals, which may be used, for instance, to reduce hepatic neutral fat. The present disclosure also relates to the use of the Lactobacillus paracasei strain as an agent to prevent or treat a disease, including fatty liver, non-alcoholic steatohepatitis, and liver cirrhosis.