Lactic Acid Bacteria Composition for Chronic Kidney Disease Management
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Solution Overview
Problem
Chronic kidney disease patients with stages 3-4 often experience rapid deterioration due to non-compliance with drug treatments, leading to end-stage renal disease, which imposes significant health and economic burdens, and existing treatments have side effects and inefficiencies in managing renal function and associated symptoms.
Innovation Solution
A novel composition comprising Lactococcus lactis subsp. lactis LL358, Lactobacillus salivarius L5159, and Lactobacillus pentosus, which is administered to modify or delay the progression of chronic kidney disease, maintaining renal function, preventing metabolic syndrome, and reducing symptoms such as hyperuricemia and hypocalcemia, available in various forms like solid, liquid, powder, tablets, food, or beverages.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If drug treatment is used to control chronic kidney disease progression, then renal function can be maintained, but side effects occur and patient compliance is poor
Solution Approach 1:
The patent introduces lactic acid bacteria as an intermediary substance that mediates the treatment of chronic kidney disease. Instead of using drugs directly that cause side effects, the lactic acid bacteria act as a biological mediator that produces beneficial effects through fermentation and metabolic activities in the gastrointestinal tract, thereby maintaining renal function without the harmful side effects of conventional drugs.
Solution Approach 2:
The patent replaces the mechanical/chemical drug treatment system with a biological system. Instead of administering chemical compounds that interfere with physiological processes and cause side effects, the invention uses living lactic acid bacteria that naturally colonize the gut and produce therapeutic effects through their metabolic activities, substituting a harsh chemical approach with a gentler biological approach.
2Reliability
If drug treatment is used to control chronic kidney disease, then progression can be slowed, but patient compliance is poor leading to rapid deterioration
Solution Approach 1:
The lactic acid bacteria perform self-service by naturally colonizing the patient's gastrointestinal tract and continuously producing therapeutic effects without requiring active patient management. The bacteria self-replicate and maintain their population in the gut, providing ongoing treatment that automatically adapts to the patient's physiological conditions, thereby ensuring consistent compliance without relying on patient memory or motivation.
Solution Approach 2:
The lactic acid bacteria serve as a living intermediary that bridges the gap between patient and disease. Rather than requiring patients to actively manage complex drug regimens, the bacteria continuously mediate the therapeutic effect through their presence and metabolic activities in the gut, making the treatment process passive and highly compliant for patients.
3Object-affected harmful factors
If conventional treatment is used for chronic kidney disease, then some symptoms can be controlled, but end-stage renal disease still occurs requiring dialysis
Solution Approach 1:
The lactic acid bacteria perform preliminary protective actions by continuously producing beneficial substances in the gastrointestinal tract that prevent the development of uremic toxins and inflammatory mediators before they can cause damage to renal function. This proactive prevention mechanism addresses the root causes of disease progression rather than merely controlling symptoms, thereby preventing progression to end-stage renal disease.
Solution Approach 2:
The lactic acid bacteria convert potentially harmful substances in the gastrointestinal tract into beneficial compounds. They ferment dietary components and metabolites that would otherwise contribute to uremic toxin formation, converting these harmful substances into short-chain fatty acids and other beneficial metabolites that protect renal function and prevent disease progression to end-stage requiring dialysis.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively reduces systolic and diastolic blood pressure, improves renal function indices, and ameliorates metabolic syndrome markers, leading to better quality of life and delayed disease progression in chronic kidney disease patients by promoting renal health and reducing symptom severity.
Implementation Method 1
Lactic acid bacteria are microorganisms able to produce lactic acid through fermentation of hydrocarbons
Data Source
AI summary
Lactic acid bacteria, which are isolated Lactococcus lactis subsp. lactis LL358 and isolated Lactobacillus salivarius LS159 respectively. By administering a composition comprising the lactic acid bacteria of the invention, renal injury, metabolic syndrome, hyperuricemia, hypocalcemia, and other disorders can be effectively ameliorated or treated.