Lysozyme Peptide Hydrolysate for Inhibitory Control and Impulsivity
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Solution Overview
Problem
There is a need for improving or maintaining cognitive functions such as inhibitory control, proactive inhibitory control, attention, sustained attention, control of impulsivity, and alertness in healthy individuals and for treating impaired cognitive functions in individuals with neurodegenerative diseases or other health issues that affect these functions.
Innovation Solution
Administering a composition comprising subtilisin A hydrolysate of lysozyme to enhance cognitive functioning, particularly through improving inhibitory control, proactive inhibitory control, attention, and control of impulsivity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If no intervention is provided, then cognitive functions naturally decline over time due to ageing and disease, but administering substances or therapies may introduce complexity to the solution
Solution Approach 1:
The patent changes the chemical parameter of the peptide structure by using specific hydrolysates with controlled molecular weights (0.5-10 kDa) and degree of hydrolysis (10-50%), thereby improving cognitive function stability without complex delivery systems
Solution Approach 2:
The patent employs readily available food-grade proteins (casein, soy, milk, egg, wheat) that can be easily hydrolyzed and administered through simple oral intake, avoiding complex therapeutic interventions
2Reliability
If conventional treatments are used for impaired cognitive function, then some improvement may be achieved, but the treatments often have limited efficacy or require high doses with potential side effects
Solution Approach 1:
The patent optimizes the degree of hydrolysis (10-50%) and molecular weight distribution (0.5-10 kDa) of the peptide hydrolysates to maximize cognitive benefits while minimizing potential adverse effects, achieving improved reliability without harmful factors
Solution Approach 2:
The patent uses homogeneous peptide mixtures from natural food sources that are biocompatible and reduce the risk of immune reactions or side effects compared to synthetic compounds
3Measurement precision
If highly processed therapeutic compounds are administered, then cognitive function may be targeted more specifically, but the manufacturing complexity and cost increase
Solution Approach 1:
The patent segments proteins into specific molecular weight ranges (0.5-10 kDa) through controlled hydrolysis, achieving targeted cognitive benefits while maintaining simple manufacturing processes using conventional hydrolysis methods
Solution Approach 2:
The patent uses multi-functional peptide hydrolysates that can be derived from various natural sources (casein, soy, milk, egg, wheat) and serve both nutritional and cognitive enhancement functions, simplifying manufacturing while maintaining precision
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The subtilisin A hydrolysate of lysozyme improves cognitive functions by at least 0.5% to 10% in healthy individuals and up to 3% in those with impaired cognitive functions, as measured by psychomotor vigilance and anticue tasks, effectively enhancing alertness and impulse control.
Implementation Method 1
a subtilisin A hydrolysate of lysozyme, wherein at least 10%, preferably at least 20%, more preferably at least 30% by weight of the subtilisin A hydrolysate of lysozyme are lysozyme peptides with a molecular weight of less than 1,000 Dalts
Implementation Method 2
The composition comprises a protein lysate, more in particular a lysozyme lysate, the lysate being a subtilisin A hydrolysate of lysozyme
Data Source
Figure 1
AI summary
The invention relates to a non-therapeutic method of improving or maintaining cognitive functioning in a subject, the method comprising administering to the subject a composition comprising subtilisin A hydrolysate of lysozyme. Furthermore, the invention relates to a subtilisin A hydrolysate of lysozyme for use in a method for the treatment of impaired cognitive functioning in a subject in need thereof. In addition, the invention relates to the use of a nutraceutical, a food product, a functional food, a food stuff, a food ingredient, a food supplement and/or a feed product, comprising a subtilisin A hydrolysate of lysozyme, in the non-therapeutic method of improving or maintaining cognitive functioning in a subject, or a nutraceutical, a food product, a functional food, a food stuff, a food ingredient, a food supplement and/or a feed product, comprising a subtilisin A hydrolysate of lysozyme, for use in the method for the treatment of impaired cognitive functioning in a subject in need thereof.