Manganese MRI Composition for Nonfasting Liver Cancer Imaging
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Solution Overview
Problem
Current MRI compositions require fasting before administration to maintain imaging quality, which is inconvenient and poses health risks for some subjects, and existing oral manganese-based agents result in low signal enhancement when not fasting.
Innovation Solution
An MRI composition comprising manganese (II) compounds, proteinogenic amino acids, and vitamin D, administered with a meal of predefined calorie content below 500 kcal, allows imaging quality comparable to fasting without prolonged fasting.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If subjects fast for prolonged periods (>8 h) prior to MRI composition administration, then imaging quality is maintained, but subject convenience deteriorates and health risks increase
Solution Approach 1:
The patent changes the parameter of fasting duration from a strict requirement (>8 hours) to a flexible window (0-8 hours before administration), allowing subjects to consume meals with controlled calorie content (≤500 kcal) while maintaining acceptable imaging quality. This parameter modification resolves the contradiction by enabling both reasonable convenience and adequate diagnostic performance.
2Ease of operation
If subjects consume a full meal prior to MRI composition administration, then subject convenience improves, but imaging quality deteriorates due to low signal enhancement
Solution Approach 1:
The patent introduces a calorie content parameter (≤500 kcal) as a new constraint on meal consumption, transforming the binary choice between fasting and full meal into a controlled feeding regime. This allows subjects to consume meals for convenience while limiting the negative impact on manganese absorption and signal enhancement, thus resolving the quality-convenience trade-off.
3Ease of operation
If subjects consume a meal with calorie content ≤500 kcal prior to administration, then subject convenience improves and health risks are reduced, but imaging quality may be compromised compared to fasting
Solution Approach 1:
The patent converts the previously harmful effect of food consumption (which reduced signal enhancement) into a beneficial or neutral factor by establishing controlled feeding conditions. By allowing meals ≤500 kcal, the patent transforms the harm of food interference into a manageable parameter that can be optimized, enabling convenience without severe quality loss and potentially reducing fasting-related harms.
4Measurement precision
If prolonged fasting is required for MRI composition administration, then imaging quality is maintained, but health risks and inconvenience increase for some subjects
Solution Approach 1:
The patent modifies the fasting duration parameter from a strict prolonged fast (>8 hours) to a flexible regimen allowing meals within 0-8 hours before administration with calorie content ≤500 kcal. This parameter change eliminates the need for extended fasting, thereby removing associated health risks such as hypoglycemia, dehydration, and discomfort, while maintaining acceptable imaging quality through controlled feeding.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables high-quality MRI diagnosis of liver metastases and primary liver cancer without the need for prolonged fasting, reducing health risks and inconvenience.
Implementation Method 1
MRI is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body. MRI scanners use strong magnetic fields, magnetic field gradients, and radio waves to generate images of the organs in the body.
Implementation Method 2
it has now been shown that the absorption of manganese from the gastrointestinal tract can be enhanced by the use of vitamin D and/or amino acids
Implementation Method 3
the absorption of manganese from the gastrointestinal tract can be enhanced by the use of vitamin D and/or amino acids
Data Source
AI summary
The present invention relates to an oral Magnetic Resonance Imaging (MRI) composition and its use in diagnosis in vivo of liver metastases and/or primary liver cancer in subjects having consumed a predefined meal.