Multipurpose Medical Image Indicator for Laparoscopic Lesion Detection
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Solution Overview
Problem
Current methods for locating tumors during laparoscopic surgery, such as early gastric or colon cancer, are invasive and lack real-time visual identification, making it difficult to accurately mark and remove lesions without damaging surrounding tissues.
Innovation Solution
A multipurpose medical image indicator using a combination of fluorophores and MRI or CT contrast agents integrated into a rubber material for endoscope ligation, allowing for non-invasive real-time visualization of lesions through a ligation device, comprising Indocyanine Green, Rose Bengal, ATTO, Alexa, Rhodamine, and other dyes, along with gadolinium or iodine-based contrast agents, which are mixed with rubber material and crosslinked for durability and stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If traditional tumor marking methods (tattoo method, clip installation) are used during laparoscopic surgery, then lesion location can be identified, but the methods are invasive and not suitable for real-time visual identification
Solution Approach 1:
The patent combines multiple imaging modalities (fluorescence imaging, MRI, and CT) into a single medical image indicator composed of rubber material containing fluorophores and contrast agents. This merging allows the indicator to provide real-time fluorescence guidance during surgery while also offering preoperative MRI/CT visualization and postoperative verification, eliminating the need for separate marking methods
Solution Approach 2:
The medical image indicator is designed with multi-functionality to serve multiple purposes: it provides real-time fluorescence imaging during laparoscopic surgery for precise lesion identification, enables preoperative planning through MRI and CT imaging, and allows postoperative verification of complete tumor removal. This universal indicator replaces multiple separate marking techniques
2Speed
If direct visual observation during laparoscopic surgery is used, then real-time identification is possible, but it is impossible to check tumor sites and organs by directly sensing them with hands
Solution Approach 1:
The patent replaces the mechanical tactile sensing system (direct hand sensing) with an optical imaging system. The fluorescence-based medical image indicator allows surgeons to visually detect tumor sites, margins, and lymph nodes in real-time during laparoscopic surgery through fluorescence imaging, compensating for the loss of tactile feedback by providing enhanced visual information
3Adaptability or versatility
If multiple imaging modalities are combined in one indicator, then comprehensive imaging capability is achieved, but the device complexity increases
Solution Approach 1:
The patent employs composite materials science by formulating a rubber-based material that simultaneously incorporates fluorophores (for fluorescence imaging), MRI contrast agents (for magnetic resonance imaging), and CT contrast agents (for computed tomography). This composite structure allows multiple imaging modalities to be integrated into a single indicator without requiring separate components, managing complexity through material science
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables precise and swift detection of lesions, reducing operation time and minimizing tissue removal by providing accurate, non-invasive imaging before and after surgery and radiotherapy.
Implementation Method 1
the multipurpose medical image indicator including rubber material and fluorophores
Implementation Method 2
the MRI contrast agent is composed of a gadolinium complex, a mangan complex or an oxidized steel nanoparticle
Implementation Method 3
the CT agent is composed of a metal, a complex including iodine, or a nanoparticle
Data Source
AI summary
The present disclosure concerns a medical image indicator. More particularly, it concerns the multipurpose medical image indicator including more than one of fluorophores and MRI contrast agent/CT contrast agent and method for manufacturing same. Responding to a demand for non-invasive and effective way of marking lesions, the present disclosure provides a method for manufacturing the multipurpose medical image indicator including a provision of rubber material fluid composition; a mixing of the rubber material fluid composition and fluorophores; and a transfiguring and drying of the mixture and the multipurpose medical image indicator manufactured according to the method. Further, the present disclosure provides a ligation device for endoscope including the multipurpose medical image indicator.