Mesenchymal Stem Cell Therapy for Female Sexual Dysfunction

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Solution Overview

Problem

There are few effective treatment options for female sexual dysfunction (FSD), particularly hypoactive sexual desire disorder, orgasmic disorder, and sexual arousal disorder, which are often associated with significant negative side effects from hormonal and psycho-affective drugs.

Innovation Solution

Administering a therapeutically effective amount of isolated human mesenchymal stem cells, such as bone marrow-derived, cord blood-derived, or adipose tissue-derived, to patients suffering from sexual dysfunction, either as a single dose or multiple doses, to increase libido and sexual satisfaction.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If hormonal or psycho-affective drugs are used to treat female sexual dysfunction, then sexual dysfunction is treated, but serious negative side effects occur

Engineering Contradiction:

Improveeffectiveness of treatmentVSAvoidnegative side effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent introduces mesenchymal stem cells as an intermediary substance to treat female sexual dysfunction. These stem cells act as a mediator that modulates the sexual response system without requiring hormonal or psycho-affective drugs, thereby achieving treatment effectiveness while avoiding the serious negative side effects associated with conventional pharmaceutical interventions

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent changes the fundamental parameter of treatment from chemical/pharmacological agents to biological stem cells. This parameter change allows the treatment to work through different mechanisms (stem cell differentiation, paracrine signaling, immunomodulation) that do not produce the harmful side effects of conventional drugs while maintaining therapeutic effectiveness

Inventive Principle:

Principle #35Parameter changes

2Device complexity

If few treatment options are available for female sexual dysfunction, then treatment simplicity is maintained, but treatment effectiveness is limited

Engineering Contradiction:

Improvenumber of treatment optionsVSAvoidtreatment effectiveness

Core Design Contradiction:

Device complexityVSReliability

Solution Approach 1:

The patent extracts and isolates mesenchymal stem cells from their natural source (bone marrow, umbilical cord, or adipose tissue) to create a purified therapeutic product. This extraction process enables the development of a standardized treatment that can be administered without requiring complex surgical procedures or multiple different treatment modalities, thereby improving treatment effectiveness while maintaining simplicity

Inventive Principle:

Principle #2Taking out (Extraction)

Data Source

PatentUS12496316B2Treatment of sexual dysfunction and improvement in sexual quality of life

Publication Date: 2025.12.16 LONGEVERON INC

AI summary

Compositions and methods for treating sexual dysfunction and enhancing sexual satisfaction using isolated populations of mesenchymal stem cells are disclosed.