Microneedle Patch With Viscosity-Reducing Adhesion Layer
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Solution Overview
Problem
Current dermal fillers, such as PLLA, often cause side effects like bruising, redness, and inflammatory reactions due to their injection form, which requires medical expertise and can lead to uneven distribution and excessive concentration of the active substance.
Innovation Solution
A microneedle design featuring a supporting portion, a needle tip portion containing an active substance, and an adhesion layer with a viscosity-reducing substance, allowing for controlled release of the active substance into the skin with reduced side effects and improved distribution.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If injection form is used for dermal fillers, then the active substance can be delivered to the skin, but it causes blood stasis, hematoma, and pain due to difficulty in controlling injection location and dose
Solution Approach 1:
The microneedle patch divides the delivery system into multiple independent microneedles arranged in an array, with each needle capable of delivering a controlled portion of the active substance. This segmentation allows precise control over injection location and dose distribution across multiple puncture points, eliminating the uncontrolled injection issues of traditional single-point injection methods
Solution Approach 2:
The microneedles are designed to automatically penetrate the skin and release the active substance without requiring manual injection control by a doctor. The patch applies itself to the skin and the microneedles self-insert and self-deliver the active substance, eliminating the need for skilled manual injection and the associated risks of blood stasis, hematoma, and pain
2Duration of action of stationary object
If PLLA filler is used, then semi-permanent filling effect is achieved, but it causes skin bruising, redness, swelling, itching and pain due to irregular flake crystals with sharp corners
Solution Approach 1:
The microneedles deliver the PLLA filler directly to specific target locations in the skin through controlled puncture, concentrating the active substance at the exact needed sites rather than spreading it through uncontrolled injection. This localized delivery reduces the harmful effects of sharp PLLA crystals by limiting their distribution to precise treatment areas, minimizing bruising, redness, and inflammation
Solution Approach 2:
The invention changes the delivery parameters by using microneedles with controlled lengths and angles to penetrate the skin at specific depths and orientations. This controlled parameter delivery ensures the PLLA filler is placed precisely in the dermal layer without causing the excessive tissue stimulation and inflammatory reactions associated with conventional injection methods
3Productivity
If traditional injection method is used, then the active substance can be administered, but it requires about a week of postoperative recovery period and daily massage
Solution Approach 1:
The microneedles are pre-loaded with the active substance and designed to deliver it immediately upon skin penetration. The patch is pre-configured with the microneedle array and active substance reservoir, so that when applied to the skin, the delivery process begins automatically without requiring postoperative intervention such as daily massage, thereby reducing the recovery period
4Reliability
If conventional injection is used, then the active substance is delivered, but the results vary depending on the doctor's operating skills
Solution Approach 1:
The microneedle patch system is designed to be self-applying and self-delivering, eliminating the need for skilled manual injection by the doctor. The patch adheres to the skin and the microneedles automatically penetrate and release the active substance according to pre-programmed parameters, ensuring consistent and reproducible results that do not vary with operator skill level
Solution Approach 2:
The invention standardizes the delivery parameters through controlled microneedle design, including fixed needle lengths, angles, and insertion depths. These predetermined parameters ensure consistent active substance delivery regardless of who applies the patch, eliminating the variability in results caused by differences in doctor's operating skills
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The microneedle system enables accurate control over the release location and dose of the active substance, dispersing it evenly across multiple puncture units to minimize adverse reactions and enhance collagen regeneration.
Implementation Method 1
the adhesion layer includes an adhesive material and a viscosity-reducing substance distributed in the adhesive material
Data Source
AI summary
A microneedle is provided in some embodiments of the present disclosure, including a supporting portion, a needle tip portion and an adhesion layer. The needle tip portion is disposed above the supporting portion, including an active substance. The adhesion layer is disposed between the supporting portion and the needle tip portion, including an adhesive material and a viscosity-reducing substance distributed in the adhesive material. A microneedle patch and a method are further provided in some embodiments of the present disclosure.