Bending the sheet body transitions microneedles from a flat storage state to a raised application position, preventing accidental contact during handling.
A hybrid method forms microstructure array molds using electroplated metal base layers to replicate complex geometries.
HPMC and PVP/VA composites prevent brittleness during drying, ensuring structural integrity and skin adhesion.
Selective etching of a sacrificial porous silicon layer allows damage-free transfer of nanoprojection arrays to flexible substrates.
A nozzle with a concave-convex end portion holds sheet-like water-soluble preparations for reliable skin application.
A smart adapter embeds sensors to detect drug concentration and flow rate in infusion systems.
Photolithography creates crosslinked biopolymer microneedles that bypass the stratum corneum barrier to deliver large hydrophilic molecules without degradation.
A segmented microneedle array combines hollow drug delivery protrusions with solid blood flow promoters to optimize transdermal absorption.
A microneedle patch delivers insulin through hollow needles while a sensor measures sweat glucose levels for automated control.
Front plate adhesive injection bonds cap part and housing simultaneously, eliminating complex rear-side filling defects.
Freeze-thaw treatment creates physical cross-links in polymeric microneedles, delivering large molecular weight therapeutics without protein denaturation.
A microneedle patch uses an adhesion layer with a viscosity-reducing substance to control active substance release from the needle tip.
Polymeric female die mediates metal mold alignment, correcting microneedle position deviations to boost production yield.