Microneedles TRIZ Cases

Bending the sheet body transitions microneedles from a flat storage state to a raised application position, preventing accidental contact during handling.

A hybrid method forms microstructure array molds using electroplated metal base layers to replicate complex geometries.

HPMC and PVP/VA composites prevent brittleness during drying, ensuring structural integrity and skin adhesion.

Selective etching of a sacrificial porous silicon layer allows damage-free transfer of nanoprojection arrays to flexible substrates.

A nozzle with a concave-convex end portion holds sheet-like water-soluble preparations for reliable skin application.

A smart adapter embeds sensors to detect drug concentration and flow rate in infusion systems.

Photolithography creates crosslinked biopolymer microneedles that bypass the stratum corneum barrier to deliver large hydrophilic molecules without degradation.

A segmented microneedle array combines hollow drug delivery protrusions with solid blood flow promoters to optimize transdermal absorption.

A microneedle patch delivers insulin through hollow needles while a sensor measures sweat glucose levels for automated control.

Front plate adhesive injection bonds cap part and housing simultaneously, eliminating complex rear-side filling defects.

Freeze-thaw treatment creates physical cross-links in polymeric microneedles, delivering large molecular weight therapeutics without protein denaturation.

A microneedle patch uses an adhesion layer with a viscosity-reducing substance to control active substance release from the needle tip.

Polymeric female die mediates metal mold alignment, correcting microneedle position deviations to boost production yield.

A microneedle patch applicator housing features a raised part designed for uniform vertical deformation during skin application.

A transdermal microneedle patch uses detachable covers to separate the disposable sensing array from the reusable signal processing unit.

Flexible microneedle bonded to a rigid support section with an adhesive extension anchors the device against skin elasticity.

A microneedle applicator uses interlocking guide members to constrain array orientation during insertion.

An applicator with a bending portion and elastic member applies consistent pressing force to resolve variations in active ingredient administration.

A sterile applicator assembly attaches to a syringe, featuring flexible tendrils and a detachable microneedle platform for precise fluid delivery.

Segmenting drug quantity via dynamic reservoir positioning resolves the trade-off between steady-state concentration and variable administration rates.

Open channel cross-sectional geometry drives passive capillary wicking of liquid drug formulations through microneedles.

Vacuum centrifugal filling removes gas entrapment to ensure precise base material deposition into microneedle mold grooves.

A roller actuator peels a transdermal patch on and off skin, resolving the trade-off between fixed-schedule simplicity and precise adaptive dosing.

A microneedle applicator eliminates a shaft using a conical coil spring and piston plate, reducing size and weight while maintaining reliability.

A micro needle applicator holding part secures the array while an insertion assist part forms a complete state where the central region protrudes further than the peripheral side.

A microneedle structure uses a separation layer and wire-type pores to enable rapid deployment and controlled drug release.

Freezing aqueous solutions creates solid microneedles that maintain cell viability while penetrating skin for targeted cancer immunotherapy delivery.

Thickening the outer edge of a transdermal sheet distributes puncture stress and prevents skin deviation during drug delivery.

A microneedle patch uses a peripheral bump array to absorb external stress and protect fragile needles.

A microneedle array device uses flexible connecting members to transition needles from a recessed position to skin contact.

Tissue compression in the receiving space creates a seal that prevents backflow along the insertion pathway, improving drug distribution.

Segmenting the microneedle array from the drug matrix resolves device complexity and limited delivery capacity in transdermal patches.

An offset sensing microneedle detects skin contact impedance to prevent wet injections when a wearable device is improperly attached.

A beveled microneedle with a tip angle under 20 degrees enables precise suprachoroidal drug delivery.

Stepped guide grooves in the micro-needle tip segment the melting process to deliver a fixed medicine quantity quickly without partial residue.

Low-to-high pressure cycling fills intaglio recesses with acicular body-forming liquid, preventing air bubbles that cause incomplete filling.

A hollow microneedle with a beveled tip creates a larger opening to overcome inconsistent transdermal drug delivery.

Non-orthogonal surfaces and a passage stop guide microneedles to shallow skin layers, preventing leakage and deep delivery errors.

A bladder arrangement with a flexible membrane and rigid member defines a drug chamber, enabling steady infusion via an expandable hydrogel pressure source.

Force feedback sensors in a microneedle application device measure skin interaction forces to correct positioning errors and ensure consistent array deployment.

Photolithography and dry etching fabricate solid microneedles with precise geometry, overcoming limitations in conventional manufacturing dimensions.

Peripheral piston plate protrusions resist skin elastic bounce, ensuring stable microneedle insertion and reliable active ingredient transfer.

Orient adhesive layers perpendicular to skin stretching direction to prevent microneedle array detachment during puncturing.

A modified female Luer connector with a 6% internal conical taper reduces fluid dead space volume.

Segmented columnar and tapered projections balance mechanical strength against sharpness to resolve deformation risks during transdermal drug delivery.

Solid microneedles penetrate the skin barrier to deliver therapeutic agents, eliminating injection pain and discomfort.

A microneedle applicator uses a spring lever and lock mechanism to deliver consistent biasing force during skin penetration.

A galvanoplastic method builds microneedle walls inside substrate concavities using electrodeposition on conductive layers.

A cell transplantation device merges an accommodating portion with a penetrating portion to deliver cell groups directly into target tissue layers.