Micronized Myrosinase Powder for Isothiocyanate Conversion
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Solution Overview
Problem
Processed foods containing glucosinolate (GSL) often fail to efficiently convert GSL to isothiocyanate (ITC) due to inactivation of myrosinase during manufacturing, leading to low conversion efficiency when ingested.
Innovation Solution
Micronizing a powder with myrosinase activity and blending it with a GSL-containing powder to create a powdery food, where the mean volume diameter of the micronized powder is less than 500 μm, promoting the conversion of GSL to ITC upon ingestion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If heating is applied during manufacturing to process GSL-containing foods, then the food processing is completed, but myrosinase is inactivated leading to low conversion efficiency of GSL to ITC
Solution Approach 1:
The invention separates the GSL-containing component and the myrosinase-containing component into different powders, then blends them in a micronized form. This segmentation allows each component to be processed independently without inactivating the enzyme, while still achieving the desired conversion effect when consumed together.
Solution Approach 2:
The invention performs micronization on the powders before blending, creating a fine particle structure that facilitates subsequent conversion. This preliminary physical processing enables the myrosinase and GSL to be in close proximity for efficient conversion without requiring heating that would inactivate the enzyme.
2Ease of operation
If GSL is consumed in processed foods or supplements without chewing, then consumption is convenient, but conversion to ITC is minimal due to lack of mechanical breakdown
Solution Approach 1:
The invention transitions from macro-scale food items requiring mechanical chewing to micro-scale powdered particles. By reducing the particle size through micronization, the physical barrier to conversion is eliminated at the cellular level, allowing the myrosinase-GSL conversion to occur efficiently even without chewing, thus solving the contradiction between ease of consumption and conversion efficiency.
3Productivity
If micronization is performed to enhance myrosinase activity, then conversion efficiency improves, but manufacturing complexity increases
Solution Approach 1:
The invention changes the physical parameter of particle size from macro to micro scale through micronization. This parameter change fundamentally alters the interaction between myrosinase and GSL, enabling efficient conversion without requiring complex enzymatic processing or additional manufacturing steps beyond standard powder blending operations.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enhances the conversion efficiency of GSL to ITC within the body, ensuring effective bioactivation of GSL when consumed as a powdery food.
Implementation Method 1
The conversion of GSL to ITC is performed by myrosinase. Myrosinase is an enzyme that exists in cruciferous vegetables and in vivo such as in the human bowel.
Data Source
AI summary
A powdery food containing at least a micronized first powder having myrosinase activity and a second powder containing a glucosinolate.