Modular Sample Analysis System for Multi-Assay Integration
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current systems for analyzing biological samples are limited in their ability to simultaneously process and analyze both nucleic acids and proteins, requiring multiple tests on different instruments and lacking flexibility and efficiency.
Innovation Solution
A modular system that combines sample preparation and analysis in a single cartridge, allowing for multiple assays, including real-time PCR and immunoassays, with interchangeable frames and optical devices for flexible assay configurations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If multiple tests are performed on multiple different instruments, then comprehensive analysis results are obtained, but system complexity and operational time increase
Solution Approach 1:
The patent combines multiple assay capabilities (nucleic acid analysis and protein analysis) into a single integrated system with a shared sample processing chamber and optical detection system, eliminating the need for multiple separate instruments while maintaining comprehensive analytical capability
Solution Approach 2:
The system employs a universal sample processing chamber and optical device that can perform multiple different assays (real-time PCR, endpoint PCR, immunoassays) through software control and reagent variation, allowing one instrument to replace multiple specialized instruments
2Adaptability or versatility
If multiple tests are performed on multiple different instruments, then comprehensive analysis results are obtained, but time consumption increases
Solution Approach 1:
The patent combines multiple assay workflows into a single instrument with unified sample processing and detection systems, allowing sequential or parallel execution of multiple assays without the time penalty of physical sample transfer between instruments
Solution Approach 2:
The system maintains continuous operational capability by allowing multiple assays to be queued and executed sequentially in the same chamber without idle time for sample repositioning, and enables parallel processing of multiple samples through the shared optical detection system
3Ease of repair
If a modular system with interchangeable frames is used, then system flexibility and ease of repair are improved, but device complexity increases
Solution Approach 1:
The system is divided into modular functional units (frames) that can be independently removed, replaced, or repaired. Each frame contains specific assay components that can be swapped without affecting other parts of the system, simplifying maintenance while providing flexibility
Solution Approach 2:
The modular frames are designed with standardized interfaces and mounting mechanisms that allow different assay configurations to be installed in the same physical location, providing versatility without requiring complex customization for each assay type
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables efficient and flexible analysis of biological samples by allowing multiple assays to be performed in a single cartridge, reducing the need for multiple instruments and facilitating easy upgrades or repairs without downtime.
Implementation Method 1
a first optical device configured to perform a first optical analysis of a first assay performed in a first region of the cartridge
Implementation Method 2
a second optical device configured to perform a second optical analysis of a second assay performed in a second region of the cartridge
Data Source
AI summary
Apparatus and methods for analyzing samples, including for example, samples containing nucleic acids, antibodies, and/or antigens are described. The apparatus may include a frame having a cartridge receiver, two optical devices, thermal cycler, lysis assembly, hybridization heater, and sample transfer assembly. In use, the apparatus may perform multiple sample preparation and analysis processes within the same disposable cartridge including, for example, performing a PCR assay and immunoassay in the same cartridge.