Heating Or Cooling Apparatus TRIZ Cases

A computer-implemented method adjusts the thermal block ramp rate in real-time to synchronize sample and block temperatures during PCR cycling.

A temperature control device segments active heating and passive cooling zones on a substrate to manage fluid temperatures.

Silicon integrated circuit photodiodes detect fluorescence from microwells, eliminating bulky fluorescent microscopes and reducing system complexity.

Temperature-based addressing of nucleic acid molecules increases storage density by eliminating physical barriers and reducing primer requirements.

Automated specimen processing systems use opposable elements to control reagent volumes and temperatures, reducing waste while maintaining staining consistency.

Diverging microchannel walls use surface tension to form and move droplets without carrier fluid, reducing sample loss in digital PCR.

Integrating a DC heater into the fluidic chip eliminates external cyclers, reducing handling errors in portable DNA testing.

Segmented cartridge merges RT-LAMP amplification and CRISPR detection to reduce loss of time while maintaining measurement precision.

A modular analysis system combines sample preparation and detection in a single cartridge to execute multiple assays simultaneously.

Baseline fluorescence thresholds eliminate primer-dimer false positives, ensuring accurate point-of-care diagnosis.

A temperature conditioning unit uses a high-conductivity heat member and low-conductivity support to stabilize imaging distance.

Sealed reagent compartments within the cartridge prevent cross-contamination during automated transfer, eliminating manual handling risks.

Orthogonally cleavable linkers detach solid-phase PCR reagents into solution, resolving slow surface hybridization rates.

Immobilized molecular beacons emit fluorescence upon hybridizing with target nucleic acids for direct optical detection.

A portable device circulates biological samples through a matrix chamber using an integrated pump and heating element.

An integrated cartridge merges sample preparation and optical detection into a single unit.

Disposable cassette enables automated nucleic acid detection via integrated microfluidic channels and resistive heating elements.

Deformable connector layers seal and route fluid between reservoirs and conduits, enabling complex pathogen detection without specialized operator training.

A digital microfluidic nucleic acid detection chip uses electrode arrays to move large-volume droplets for hybridization color development.

Serpentine channels in a microfluidic card route fluids through independent heating zones, reducing PCR cycle times below two seconds.

Diagnostic device with multiple reaction chambers and probes enables simultaneous nucleic acid detection, eliminating complex laboratory processing.

A microfluidic chip uses spatial temperature zones to cycle fluid through distinct thermal regions for nucleic acid amplification.

A microfluidic apparatus with parallel filtering and pumping branches isolates sample constituents using adjustable channel-crossover elements.

Segmented disposable cartridge with wax barrier prevents bubbles during pneumatic mixing, reducing equipment complexity while maintaining detection precision.

Segmenting the preparation and amplification zones with a capillary break prevents evaporation during thermal processing, maintaining sample volume stability.

Alternating excitation light flashes with specific phase differences minimizes interference between overlapping fluorescence detection channels.

Heating elements surround multiple sides of fluid chambers to enable rapid, uniform thermal cycling and parallel sample processing.

A power control system adjusts individual heating element duty cycles to ensure consistent thermal output across the furnace cavity.

Tube holding device with assay-specific coding ensures correct positioning, reducing contamination risks during automated PCR sample preparation.

Resistive inner wall heating maintains temperature uniformity to prevent crystal precipitation.

A compact thermal cycling device uses segmented radiative heating and cooling layers to rapidly change sample temperature.

A microfluidic cassette uses a breakable seal to isolate reagents from fluid flow until activation.

A light detection device arrays multiple flow channels to detect fluorescence from droplets using perpendicular laser irradiation.

A microfluidic liquid handling device uses a common channel to route samples and reagents through integrated wells.

Periodic plunger activation breaks adhesion bonds to ensure safe automated removal of samples.

A polymeric micro-arm apparatus integrates embedded piezoresistive sensors to detect contact and measure pressure during fluidic operations.

Integrated PCR chips eliminate complex peripheral devices by using electro-wetting to move liquid drops through sequential sample, mixing, and thermal regions.

A housing-integrated assay device uses a raised tip to mechanically break a cup bottom and release liquid onto a test strip.

Segmented chambers with reinforced sealing members prevent reagent leakage and cross-contamination during vibration in genome extraction.

Active cooling element reduces desorber temperature during heating phase, eliminating idle wait time between samples to increase trace detection throughput.

Embedded heater enables 160°C/s heating rates to achieve rapid thermocycling and multiplexing in under 20 minutes.

Chemiluminescent energy transfer excites fluorophores to enable fluorescence detection, eliminating complex optical excitation systems and reducing device cost.

Integrated microfluidic cartridge combines sample extraction, nucleic acid amplification, and electrochemical detection in a single device.

Barcoded oligonucleotides in a microfluidic device fuse with cell droplets to resolve the trade-off between screening throughput and genotype recovery accuracy.

Aptamer-coated magnetic beads resolve specificity issues in multiplex virus detection by enabling selective binding and accurate identification.

Rotation of the thermal cycler disc creates turbulence that resolves non-uniform heating across sample chambers, ensuring consistent biological reaction yields.

A particle container uses a width changing unit to adjust the measurement region gap.

Differential thermal expansion between ceramic heads and polymer tips secures connections, resolving tolerance issues from inconsistent tip dimensions.

Ridges and grooves on the cap mate with the vessel body to prevent contamination and evaporation during thermal cycling.

A segmented extraction cassette uses an isolated alcohol compartment to disinfect samples while preventing contaminant spread through pressure-driven flow.