Molecule Synthesis Parameter Blocks for Flexible Reagent Control
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Solution Overview
Problem
Conventional methods for synthesizing molecules, such as oligonucleotides and oligopeptides, lack flexibility in synthesis methods, chemistry, and scale, and are inefficient in reagent use.
Innovation Solution
A computer-implemented method and device that control the synthesis process through blocks of parameters, allowing for user input to modify and optimize cycles and process steps, including global, type-specific, or selected cycle modifications, to enhance efficiency and reagent usage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If conventional methods are used for synthesizing molecules, then the synthesis process is simple to implement, but the flexibility in synthesis methods, chemistry and scale is limited and reagent efficiency is poor
Solution Approach 1:
The patent implements flexibility through parameter blocks that define synthesis conditions. Each cycle and process step can be controlled by adjustable parameters such as reagent volumes, flow rates, temperatures, and reaction times. This allows the same device to perform different synthesis methods and scales by simply changing parameter values without modifying the physical device structure.
Solution Approach 2:
The system employs dynamic control where process cycles can be repeated with modified parameters. The device transitions from static conventional methods to dynamic adaptable synthesis by allowing real-time adjustment of synthesis conditions, cycle repetitions, and parameter optimization based on specific molecular synthesis requirements.
2Productivity
If conventional synthesis methods are used, then the device structure is simple, but the efficiency in reagent use is not optimal
Solution Approach 1:
The patent implements feedback control through monitoring synthesis progress and adjusting reagent delivery accordingly. The system tracks coupling efficiency, oxidation completeness, and capping effectiveness, then optimizes subsequent reagent usage based on this feedback, minimizing waste while maintaining high productivity.
Solution Approach 2:
Reagent efficiency is improved through optimized parameter settings including precise control of reagent volumes, concentrations, and delivery timing. The system adjusts parameters such as amidite equivalents, coupling time, and wash volumes to achieve optimal reagent utilization, reducing both excess reagent waste and insufficient reaction conditions.
3Quantity of substance
If conventional synthesis methods are used, then the operation procedure is straightforward, but the synthesis scale is limited
Solution Approach 1:
The device achieves multi-functionality by combining microfluidic precision with scalable architecture. The same device can perform small-scale high-precision synthesis and scale up to larger production volumes by adjusting parameter blocks, making it universally applicable across different synthesis scales without requiring multiple specialized devices.
Solution Approach 2:
The synthesis process is segmented into modular process steps (detritylation, coupling, oxidation, capping) that can be independently controlled and optimized. This segmentation allows flexible scaling by repeating cycles with adjusted parameters, enabling the system to handle both small and large synthesis quantities through systematic repetition rather than monolithic process design.
Data Source
AI summary
The present invention relates to a computer implemented method performed by a device (600) configured to synthesize molecules, wherein the synthesizing comprises performing cycles of a plurality of process steps (PS1-PS4), wherein the synthesizing is controlled by blocks of parameters, the method comprising receiving an indication of a target molecule, generating a synthesizing process description (300) by generating a plurality of blocks (310) of parameters, each block (310) controlling process steps of a respective cycle, receiving user input indicative of modification of the generated plurality of blocks of parameters, modifying the generated plurality of blocks of parameters using the user input, controlling synthesizing of the target molecule by applying the modified plurality of blocks of parameters to control of the respective cycles.